Cargando…

CSF1R inhibition with PLX5622 affects multiple immune cell compartments and induces tissue-specific metabolic effects in lean mice

AIMS/HYPOTHESIS: Colony stimulating factor 1 (CSF1) promotes the proliferation, differentiation and survival of macrophages, which have been implicated in both beneficial and detrimental effects on glucose metabolism. However, the physiological role of CSF1 signalling in glucose homeostasis and the...

Descripción completa

Detalles Bibliográficos
Autores principales:	Bosch, Angela J. T., Keller, Lena, Steiger, Laura, Rohm, Theresa V., Wiedemann, Sophia J., Low, Andy J. Y., Stawiski, Marc, Rachid, Leila, Roux, Julien, Konrad, Daniel, Wueest, Stephan, Tugues, Sonia, Greter, Melanie, Böni-Schnetzler, Marianne, Meier, Daniel T., Cavelti-Weder, Claudia
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer Berlin Heidelberg 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10627931/ https://www.ncbi.nlm.nih.gov/pubmed/37792013 http://dx.doi.org/10.1007/s00125-023-06007-1

Ejemplares similares

Significant Sex Differences in the Efficacy of the CSF1R Inhibitor-PLX5622 on Rat Brain Microglia Elimination
por: Sharon, Aviv, et al.
Publicado: (2022)

Putting PLX5622 into perspective: microglia in central nervous system viral infection
por: Spiteri, Alanna G., et al.
Publicado: (2022)

Reply to Green and Hume: Nonmicroglia peripheral immune effects of short-term CSF1R inhibition with PLX5622
por: Lei, Fengyang, et al.
Publicado: (2021)

CSF1R inhibitor PLX5622 and environmental enrichment additively improve metabolic outcomes in middle-aged female mice
por: Ali, Seemaab, et al.
Publicado: (2020)

Low-dose PLX5622 treatment prevents neuroinflammatory and neurocognitive sequelae after sepsis
por: Mein, Nils, et al.
Publicado: (2023)

Terminal field volume of the glossopharyngeal nerve in adult rats reverts to prepruning size following microglia depletion with PLX5622
por: Riquier, Andrew J., et al.
Publicado: (2022)

PLX5622 Reduces Disease Severity in Lethal CNS Infection by Off-Target Inhibition of Peripheral Inflammatory Monocyte Production
por: Spiteri, Alanna G., et al.
Publicado: (2022)

A 14-day pulse of PLX5622 modifies α-synucleinopathy in preformed fibril-infused aged mice of both sexes
por: Bhatia, Tarun N., et al.
Publicado: (2023)

Targeting colonic macrophages improves glycemic control in high-fat diet-induced obesity
por: Rohm, Theresa V., et al.
Publicado: (2022)

Lung versus gut exposure to air pollution particles differentially affect metabolic health in mice
por: Bosch, Angela J. T., et al.
Publicado: (2023)

Diesel Exhaust Particle (DEP)-induced glucose intolerance is driven by an intestinal innate immune response and NLRP3 activation in mice
por: Bosch, Angela J. T., et al.
Publicado: (2023)

Imatinib reduces non-alcoholic fatty liver disease in obese mice by targeting inflammatory and lipogenic pathways in macrophages and liver
por: AlAsfoor, Shefaa, et al.
Publicado: (2018)

Distinguishing the effects of systemic CSF1R inhibition by PLX3397 on microglia and peripheral immune cells
por: Okojie, Akhabue K., et al.
Publicado: (2023)

Genome Sequence of Streptomyces olindensis DAUFPE 5622, Producer of the Antitumoral Anthracycline Cosmomycin D
por: Rojas, Juan D., et al.
Publicado: (2014)

Protocol for isolation and spectral flow cytometry analysis of immune cells from the murine exocrine and endocrine pancreas
por: Steiger, Laura, et al.
Publicado: (2023)

Islet inflammation in type 2 diabetes
por: Böni-Schnetzler, Marianne, et al.
Publicado: (2019)

Phase Ib study of the combination of pexidartinib (PLX3397), a CSF-1R inhibitor, and paclitaxel in patients with advanced solid tumors
por: Wesolowski, Robert, et al.
Publicado: (2019)

Prohormone convertase 1/3 deficiency causes obesity due to impaired proinsulin processing
por: Meier, Daniel T., et al.
Publicado: (2022)

Deoxyguanosine kinase mutation F180S is associated with a lean phenotype in mice
por: Borreguero, Cédric Francis, et al.
Publicado: (2023)

IL-1beta promotes the age-associated decline of beta cell function
por: Böni-Schnetzler, Marianne, et al.
Publicado: (2021)

Novel CSF1R-positive tenosynovial giant cell tumor cell lines and their pexidartinib (PLX3397) and sotuletinib (BLZ945)-induced apoptosis
por: Thongchot, Suyanee, et al.
Publicado: (2022)

Identification of PLX4032-resistance mechanisms and implications for novel RAF inhibitors
por: Choi, Jaehyuk, et al.
Publicado: (2014)

Vitamin C sensitizes BRAF(V600E) thyroid cancer to PLX4032 via inhibiting the feedback activation of MAPK/ERK signal by PLX4032
por: Su, Xi, et al.
Publicado: (2021)

Plx1 is required for chromosomal DNA replication under stressful conditions
por: Trenz, Kristina, et al.
Publicado: (2008)

Chemokine CXCL13 in serum, CSF and blood–CSF barrier function: evidence of compartment restriction
por: Pilz, Georg, et al.
Publicado: (2020)

Obesity in Humans Is Characterized by Gut Inflammation as Shown by Pro-Inflammatory Intestinal Macrophage Accumulation
por: Rohm, Theresa V., et al.
Publicado: (2021)

Stem cell approaches for diabetes: towards beta cell replacement
por: Weir, Gordon C, et al.
Publicado: (2011)

Case Report—Secondary Antibody Deficiency Due to Endogenous Hypercortisolism
por: Sarcevic, Jelena, et al.
Publicado: (2020)

ZAK Inhibitor PLX4720 Promotes Extrusion of Transformed Cells via Cell Competition
por: Maruyama, Takeshi, et al.
Publicado: (2020)

PLX4032 resistance of patient-derived melanoma cells: crucial role of oxidative metabolism
por: Garbarino, Ombretta, et al.
Publicado: (2023)

A case report of vanishing bile duct syndrome after exposure to pexidartinib (PLX3397) and paclitaxel
por: Piawah, Sorbarikor, et al.
Publicado: (2019)

CSF circulation and dispersion yield rapid clearance from intracranial compartments
por: Hornkjøl, Martin, et al.
Publicado: (2022)

The subcommissural organ of the rat secretes Reissner's fiber glycoproteins and CSF-soluble proteins reaching the internal and external CSF compartments
por: Vio, Karin, et al.
Publicado: (2008)

Association between acquired resistance to PLX4032 (vemurafenib) and ATP-binding cassette transporter expression
por: Michaelis, Martin, et al.
Publicado: (2014)

PLX4032 Mediated Melanoma Associated Antigen Potentiation in Patient Derived Primary Melanoma Cells
por: George, Andrea L., et al.
Publicado: (2015)

Inhibition of TGF-β signaling, invasion, and growth of cutaneous squamous cell carcinoma by PLX8394
por: Siljamäki, Elina, et al.
Publicado: (2023)

Cystine/Glutamate antiporter system x(c)(-) deficiency impairs macrophage glutathione metabolism and cytokine production
por: de Baat, Axel, et al.
Publicado: (2023)

Correlation between Blood and CSF Compartment Cytokines and Chemokines in Subjects with Cryptococcal Meningitis
por: Okafor, Elizabeth C., et al.
Publicado: (2020)

Inhibition of IL-1beta improves Glycaemia in a Mouse Model for Gestational Diabetes
por: Schulze, Friederike, et al.
Publicado: (2020)

Plx1 is the 3F3/2 kinase responsible for targeting spindle checkpoint proteins to kinetochores
por: Wong, Oi Kwan, et al.
Publicado: (2005)

Cannot write session to /tmp/vufind_sessions/sess_u3mrl0lcijdbi6elpd8kqe3gbe