Engineered CHO cells as a novel AAV production platform for gene therapy delivery

The Herpes simplex virus (HSV)-based platform for production of recombinant adeno-associated viral vectors (rAAVs) yields higher titers and increased percentage of full capsids when compared to the triple transient transfection (TTT) method. However, this platform currently faces two major challenge...

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Detalles Bibliográficos
Autores principales: Nagy, Abdou, Chakrabarti, Lina, Kurasawa, James, Mulagapati, Sri Hari Raju, Devine, Paul, Therres, Jamy, Chen, Zhongying, Schmelzer, Albert E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10628118/
https://www.ncbi.nlm.nih.gov/pubmed/37932360
http://dx.doi.org/10.1038/s41598-023-46298-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10628118/
https://www.ncbi.nlm.nih.gov/pubmed/37932360
http://dx.doi.org/10.1038/s41598-023-46298-3

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