Low oral dose of 4-methylumbelliferone reduces glial scar but is insufficient to induce functional recovery after spinal cord injury

Spinal cord injury (SCI) induces the upregulation of chondroitin sulfate proteoglycans (CSPGs) at the glial scar and inhibits neuroregeneration. Under normal physiological condition, CSPGs interact with hyaluronan (HA) and other extracellular matrix on the neuronal surface forming a macromolecular s...

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Detalles Bibliográficos
Autores principales: Štepánková, Kateřina, Chudíčková, Milada, Šimková, Zuzana, Martinez-Varea, Noelia, Kubinová, Šárka, Urdzíková, Lucia Machová, Jendelová, Pavla, Kwok, Jessica C. F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10628150/
https://www.ncbi.nlm.nih.gov/pubmed/37932336
http://dx.doi.org/10.1038/s41598-023-46539-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10628150/
https://www.ncbi.nlm.nih.gov/pubmed/37932336
http://dx.doi.org/10.1038/s41598-023-46539-5

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