Cargando…

Low oral dose of 4-methylumbelliferone reduces glial scar but is insufficient to induce functional recovery after spinal cord injury

Spinal cord injury (SCI) induces the upregulation of chondroitin sulfate proteoglycans (CSPGs) at the glial scar and inhibits neuroregeneration. Under normal physiological condition, CSPGs interact with hyaluronan (HA) and other extracellular matrix on the neuronal surface forming a macromolecular s...

Descripción completa

Detalles Bibliográficos
Autores principales:	Štepánková, Kateřina, Chudíčková, Milada, Šimková, Zuzana, Martinez-Varea, Noelia, Kubinová, Šárka, Urdzíková, Lucia Machová, Jendelová, Pavla, Kwok, Jessica C. F.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10628150/ https://www.ncbi.nlm.nih.gov/pubmed/37932336 http://dx.doi.org/10.1038/s41598-023-46539-5

Ejemplares similares

The Effect of Wharton Jelly-Derived Mesenchymal Stromal Cells and Their Conditioned Media in the Treatment of a Rat Spinal Cord Injury
por: Chudickova, Milada, et al.
Publicado: (2019)

Planet of the AAVs: The Spinal Cord Injury Episode
por: Stepankova, Katerina, et al.
Publicado: (2021)

New Model of Ventral Spinal Cord Lesion Induced by Balloon Compression in Rats
por: Krupa, Petr, et al.
Publicado: (2020)

4-Methylumbeliferone Treatment at a Dose of 1.2 g/kg/Day Is Safe for Long-Term Usage in Rats
por: Štěpánková, Kateřina, et al.
Publicado: (2023)

The Effect of Human Mesenchymal Stem Cells Derived from Wharton’s Jelly in Spinal Cord Injury Treatment Is Dose-Dependent and Can Be Facilitated by Repeated Application
por: Krupa, Petr, et al.
Publicado: (2018)

Oral treatment of 4-methylumbelliferone reduced perineuronal nets and improved recognition memory in mice
por: Dubisova, Jana, et al.
Publicado: (2022)

Modified Methacrylate Hydrogels Improve Tissue Repair after Spinal Cord Injury
por: Hejčl, Aleš, et al.
Publicado: (2018)

Human Mesenchymal Stem Cells Modulate Inflammatory Cytokines after Spinal Cord Injury in Rat
por: Machová Urdzíková, Lucia, et al.
Publicado: (2014)

The Anti-Inflammatory Compound Curcumin Enhances Locomotor and Sensory Recovery after Spinal Cord Injury in Rats by Immunomodulation
por: Machova Urdzikova, Lucia, et al.
Publicado: (2015)

The Role of Green Tea Catechin Epigallocatechin Gallate (EGCG) and Mammalian Target of Rapamycin (mTOR) Inhibitor PP242 (Torkinib) in the Treatment of Spinal Cord Injury
por: Machova Urdzikova, Lucia, et al.
Publicado: (2023)

Does combined therapy of curcumin and epigallocatechin gallate have a synergistic neuroprotective effect against spinal cord injury?
por: Ruzicka, Jiri, et al.
Publicado: (2018)

Alzheimer’s Disease: Mechanism and Approach to Cell Therapy
por: Amemori, Takashi, et al.
Publicado: (2015)

Genipin and EDC crosslinking of extracellular matrix hydrogel derived from human umbilical cord for neural tissue repair
por: Výborný, Karel, et al.
Publicado: (2019)

Transplantation of neural precursors generated from spinal progenitor cells reduces inflammation in spinal cord injury via NF-κB pathway inhibition
por: Karova, Kristyna, et al.
Publicado: (2019)

The effect of 808 nm and 905 nm wavelength light on recovery after spinal cord injury
por: Svobodova, Barbora, et al.
Publicado: (2019)

Involvement of mTOR Pathways in Recovery from Spinal Cord Injury by Modulation of Autophagy and Immune Response
por: Vargova, Ingrid, et al.
Publicado: (2021)

A Comparative Analysis of Multipotent Mesenchymal Stromal Cells derived from Different Sources, with a Focus on Neuroregenerative Potential
por: Petrenko, Yuriy, et al.
Publicado: (2020)

The Effect of iPS-Derived Neural Progenitors Seeded on Laminin-Coated pHEMA-MOETACl Hydrogel with Dual Porosity in a Rat Model of Chronic Spinal Cord Injury
por: Ruzicka, Jiri, et al.
Publicado: (2019)

Highly efficient magnetic targeting of mesenchymal stem cells in spinal cord injury
por: Vaněček, Václav, et al.
Publicado: (2012)

Neurogenesis as a Tool for Spinal Cord Injury
por: Havelikova, Katerina, et al.
Publicado: (2022)

Human multipotent mesenchymal stem cells improve healing after collagenase tendon injury in the rat
por: Machova Urdzikova, Lucia, et al.
Publicado: (2014)

Therapeutic Strategies for Spinal Cord Injury
por: Jendelova, Pavla
Publicado: (2018)

Clinically Relevant Solution for the Hypothermic Storage and Transportation of Human Multipotent Mesenchymal Stromal Cells
por: Petrenko, Yuriy, et al.
Publicado: (2019)

A Combination of Intrathecal and Intramuscular Application of Human Mesenchymal Stem Cells Partly Reduces the Activation of Necroptosis in the Spinal Cord of SOD1(G93A) Rats
por: Řehořová, Monika, et al.
Publicado: (2019)

Spinal cord injury: From inflammation to glial scar
por: Leal-Filho, Manoel Baldoino
Publicado: (2011)

Moving beyond the glial scar for spinal cord repair
por: Bradbury, Elizabeth J., et al.
Publicado: (2019)

Deciphering glial scar after spinal cord injury
por: Zhang, Yu, et al.
Publicado: (2021)

Dissecting the Dual Role of the Glial Scar and Scar-Forming Astrocytes in Spinal Cord Injury
por: Yang, Tuo, et al.
Publicado: (2020)

Antioxidant Activities of 4-Methylumbelliferone Derivatives
por: Al-Majedy, Yasameen K., et al.
Publicado: (2016)

Chemical and Colloidal Stability of Polymer-Coated NaYF(4):Yb,Er Nanoparticles in Aqueous Media and Viability of Cells: The Effect of a Protective Coating
por: Nahorniak, Mykhailo, et al.
Publicado: (2023)

Polymer-coated hexagonal upconverting nanoparticles: chemical stability and cytotoxicity
por: Patsula, Vitalii, et al.
Publicado: (2023)

Telomerase expression in the glial scar of rats with spinal cord injury★
por: Yang, Mingkun, et al.
Publicado: (2012)

Understanding the Role of the Glial Scar through the Depletion of Glial Cells after Spinal Cord Injury
por: Perez-Gianmarco, Lucila, et al.
Publicado: (2023)

Corrigendum: Dissecting the Dual Role of the Glial Scar and Scar-Forming Astrocytes in Spinal Cord Injury
por: Yang, Tuo, et al.
Publicado: (2020)

Neuroinflammation and Scarring After Spinal Cord Injury: Therapeutic Roles of MSCs on Inflammation and Glial Scar
por: Pang, Qi-Ming, et al.
Publicado: (2021)

X-irradiation for inhibiting glial scar formation in injured spinal cord
por: Ning, Guangzhi, et al.
Publicado: (2013)

Understanding the NG2 Glial Scar after Spinal Cord Injury
por: Hackett, Amber R., et al.
Publicado: (2016)

Surgical Simulation of a Posttraumatic Spinal Cord Glial Scar in Rats
por: Telegin, G. B., et al.
Publicado: (2019)

New insights into glial scar formation after spinal cord injury
por: Tran, Amanda Phuong, et al.
Publicado: (2021)

Long-Term Cultures of Spinal Cord Interneurons
por: Vargova, Ingrid, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_a0q9p1oeu66hpt6n3npfic8dii