Loss of PDE4D7 expression promotes androgen independence, neuroendocrine differentiation and alterations in DNA repair: implications for therapeutic strategies

BACKGROUND: Androgen signalling remains the seminal therapeutic approach for the management of advanced prostate cancer. However, most tumours eventually shift towards an aggressive phenotype, characterised by androgen independence and treatment resistance. The cyclic adenosine monophosphate (cAMP)...

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Detalles Bibliográficos
Autores principales: Gulliver, Chloe, Huss, Sebastian, Semjonow, Axel, Baillie, George S., Hoffmann, Ralf
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10628190/
https://www.ncbi.nlm.nih.gov/pubmed/37740039
http://dx.doi.org/10.1038/s41416-023-02417-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10628190/
https://www.ncbi.nlm.nih.gov/pubmed/37740039
http://dx.doi.org/10.1038/s41416-023-02417-5

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