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Evaluation of eGFRs to Calculate Kidney Function in Adults with Severe Motor and Intellectual Disabilities
INTRODUCTION: The gold standard for evaluating kidney function is kidney inulin clearance (Cin). However, this procedure is difficult to perform in patients with neuromuscular disabilities and/or bladder dysfunction. We aimed to develop a simpler method for determining the estimated glomerular filtr...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Japan Medical Association
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10628310/ https://www.ncbi.nlm.nih.gov/pubmed/37941705 http://dx.doi.org/10.31662/jmaj.2023-0069 |
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author | Uemura, Osamu Hasegawa, Yuka Nakashima, Hideaki Otobe, Yoshihiro |
author_facet | Uemura, Osamu Hasegawa, Yuka Nakashima, Hideaki Otobe, Yoshihiro |
author_sort | Uemura, Osamu |
collection | PubMed |
description | INTRODUCTION: The gold standard for evaluating kidney function is kidney inulin clearance (Cin). However, this procedure is difficult to perform in patients with neuromuscular disabilities and/or bladder dysfunction. We aimed to develop a simpler method for determining the estimated glomerular filtration rate (eGFR) using equations and values for three biomarkers: serum creatinine (sCr), serum cystatin C (cysC), and serum beta-2 microglobulin (β2MG). This study evaluated three eGFR equations in patients with severe motor and intellectual disabilities (SMID). METHODS: We evaluated the equations using data of 18 adult SMID patients with a clinical need for creatinine clearance (Ccr). We compared the results of each equation with Ccr-based eGFR instead of Cin using mean error (ME), root mean square error (RMSE), and P30. RESULTS: Based on eGFR, the ME values of Cr, cysC, β2MG, and Ccr were 74.5, 2.3, and 6.5 mL/min/1.73 m(2), RMSE values, 92.3, 25.7, and 33.4 mL/min/1.73 m(2); and P30, 16.7%, 77.8%, and 72.2%, respectively. CONCLUSIONS: eGFR-Cr cannot be used to reliably assess kidney function in adult SMID patients. It is better to use eGFR-cysC to evaluate kidney function in this patient population. |
format | Online Article Text |
id | pubmed-10628310 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Japan Medical Association |
record_format | MEDLINE/PubMed |
spelling | pubmed-106283102023-11-08 Evaluation of eGFRs to Calculate Kidney Function in Adults with Severe Motor and Intellectual Disabilities Uemura, Osamu Hasegawa, Yuka Nakashima, Hideaki Otobe, Yoshihiro JMA J Original Research Article INTRODUCTION: The gold standard for evaluating kidney function is kidney inulin clearance (Cin). However, this procedure is difficult to perform in patients with neuromuscular disabilities and/or bladder dysfunction. We aimed to develop a simpler method for determining the estimated glomerular filtration rate (eGFR) using equations and values for three biomarkers: serum creatinine (sCr), serum cystatin C (cysC), and serum beta-2 microglobulin (β2MG). This study evaluated three eGFR equations in patients with severe motor and intellectual disabilities (SMID). METHODS: We evaluated the equations using data of 18 adult SMID patients with a clinical need for creatinine clearance (Ccr). We compared the results of each equation with Ccr-based eGFR instead of Cin using mean error (ME), root mean square error (RMSE), and P30. RESULTS: Based on eGFR, the ME values of Cr, cysC, β2MG, and Ccr were 74.5, 2.3, and 6.5 mL/min/1.73 m(2), RMSE values, 92.3, 25.7, and 33.4 mL/min/1.73 m(2); and P30, 16.7%, 77.8%, and 72.2%, respectively. CONCLUSIONS: eGFR-Cr cannot be used to reliably assess kidney function in adult SMID patients. It is better to use eGFR-cysC to evaluate kidney function in this patient population. Japan Medical Association 2023-10-02 2023-10-16 /pmc/articles/PMC10628310/ /pubmed/37941705 http://dx.doi.org/10.31662/jmaj.2023-0069 Text en Copyright © Japan Medical Association https://creativecommons.org/licenses/by/4.0/JMA Journal is an Open Access journal distributed under the Creative Commons Attribution 4.0 International License. To view the details of this license, please visit (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Original Research Article Uemura, Osamu Hasegawa, Yuka Nakashima, Hideaki Otobe, Yoshihiro Evaluation of eGFRs to Calculate Kidney Function in Adults with Severe Motor and Intellectual Disabilities |
title | Evaluation of eGFRs to Calculate Kidney Function in Adults with Severe Motor and Intellectual Disabilities |
title_full | Evaluation of eGFRs to Calculate Kidney Function in Adults with Severe Motor and Intellectual Disabilities |
title_fullStr | Evaluation of eGFRs to Calculate Kidney Function in Adults with Severe Motor and Intellectual Disabilities |
title_full_unstemmed | Evaluation of eGFRs to Calculate Kidney Function in Adults with Severe Motor and Intellectual Disabilities |
title_short | Evaluation of eGFRs to Calculate Kidney Function in Adults with Severe Motor and Intellectual Disabilities |
title_sort | evaluation of egfrs to calculate kidney function in adults with severe motor and intellectual disabilities |
topic | Original Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10628310/ https://www.ncbi.nlm.nih.gov/pubmed/37941705 http://dx.doi.org/10.31662/jmaj.2023-0069 |
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