Cargando…

Evaluation of eGFRs to Calculate Kidney Function in Adults with Severe Motor and Intellectual Disabilities

INTRODUCTION: The gold standard for evaluating kidney function is kidney inulin clearance (Cin). However, this procedure is difficult to perform in patients with neuromuscular disabilities and/or bladder dysfunction. We aimed to develop a simpler method for determining the estimated glomerular filtr...

Descripción completa

Detalles Bibliográficos
Autores principales: Uemura, Osamu, Hasegawa, Yuka, Nakashima, Hideaki, Otobe, Yoshihiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Japan Medical Association 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10628310/
https://www.ncbi.nlm.nih.gov/pubmed/37941705
http://dx.doi.org/10.31662/jmaj.2023-0069
_version_ 1785131729578622976
author Uemura, Osamu
Hasegawa, Yuka
Nakashima, Hideaki
Otobe, Yoshihiro
author_facet Uemura, Osamu
Hasegawa, Yuka
Nakashima, Hideaki
Otobe, Yoshihiro
author_sort Uemura, Osamu
collection PubMed
description INTRODUCTION: The gold standard for evaluating kidney function is kidney inulin clearance (Cin). However, this procedure is difficult to perform in patients with neuromuscular disabilities and/or bladder dysfunction. We aimed to develop a simpler method for determining the estimated glomerular filtration rate (eGFR) using equations and values for three biomarkers: serum creatinine (sCr), serum cystatin C (cysC), and serum beta-2 microglobulin (β2MG). This study evaluated three eGFR equations in patients with severe motor and intellectual disabilities (SMID). METHODS: We evaluated the equations using data of 18 adult SMID patients with a clinical need for creatinine clearance (Ccr). We compared the results of each equation with Ccr-based eGFR instead of Cin using mean error (ME), root mean square error (RMSE), and P30. RESULTS: Based on eGFR, the ME values of Cr, cysC, β2MG, and Ccr were 74.5, 2.3, and 6.5 mL/min/1.73 m(2), RMSE values, 92.3, 25.7, and 33.4 mL/min/1.73 m(2); and P30, 16.7%, 77.8%, and 72.2%, respectively. CONCLUSIONS: eGFR-Cr cannot be used to reliably assess kidney function in adult SMID patients. It is better to use eGFR-cysC to evaluate kidney function in this patient population.
format Online
Article
Text
id pubmed-10628310
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher Japan Medical Association
record_format MEDLINE/PubMed
spelling pubmed-106283102023-11-08 Evaluation of eGFRs to Calculate Kidney Function in Adults with Severe Motor and Intellectual Disabilities Uemura, Osamu Hasegawa, Yuka Nakashima, Hideaki Otobe, Yoshihiro JMA J Original Research Article INTRODUCTION: The gold standard for evaluating kidney function is kidney inulin clearance (Cin). However, this procedure is difficult to perform in patients with neuromuscular disabilities and/or bladder dysfunction. We aimed to develop a simpler method for determining the estimated glomerular filtration rate (eGFR) using equations and values for three biomarkers: serum creatinine (sCr), serum cystatin C (cysC), and serum beta-2 microglobulin (β2MG). This study evaluated three eGFR equations in patients with severe motor and intellectual disabilities (SMID). METHODS: We evaluated the equations using data of 18 adult SMID patients with a clinical need for creatinine clearance (Ccr). We compared the results of each equation with Ccr-based eGFR instead of Cin using mean error (ME), root mean square error (RMSE), and P30. RESULTS: Based on eGFR, the ME values of Cr, cysC, β2MG, and Ccr were 74.5, 2.3, and 6.5 mL/min/1.73 m(2), RMSE values, 92.3, 25.7, and 33.4 mL/min/1.73 m(2); and P30, 16.7%, 77.8%, and 72.2%, respectively. CONCLUSIONS: eGFR-Cr cannot be used to reliably assess kidney function in adult SMID patients. It is better to use eGFR-cysC to evaluate kidney function in this patient population. Japan Medical Association 2023-10-02 2023-10-16 /pmc/articles/PMC10628310/ /pubmed/37941705 http://dx.doi.org/10.31662/jmaj.2023-0069 Text en Copyright © Japan Medical Association https://creativecommons.org/licenses/by/4.0/JMA Journal is an Open Access journal distributed under the Creative Commons Attribution 4.0 International License. To view the details of this license, please visit (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Original Research Article
Uemura, Osamu
Hasegawa, Yuka
Nakashima, Hideaki
Otobe, Yoshihiro
Evaluation of eGFRs to Calculate Kidney Function in Adults with Severe Motor and Intellectual Disabilities
title Evaluation of eGFRs to Calculate Kidney Function in Adults with Severe Motor and Intellectual Disabilities
title_full Evaluation of eGFRs to Calculate Kidney Function in Adults with Severe Motor and Intellectual Disabilities
title_fullStr Evaluation of eGFRs to Calculate Kidney Function in Adults with Severe Motor and Intellectual Disabilities
title_full_unstemmed Evaluation of eGFRs to Calculate Kidney Function in Adults with Severe Motor and Intellectual Disabilities
title_short Evaluation of eGFRs to Calculate Kidney Function in Adults with Severe Motor and Intellectual Disabilities
title_sort evaluation of egfrs to calculate kidney function in adults with severe motor and intellectual disabilities
topic Original Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10628310/
https://www.ncbi.nlm.nih.gov/pubmed/37941705
http://dx.doi.org/10.31662/jmaj.2023-0069
work_keys_str_mv AT uemuraosamu evaluationofegfrstocalculatekidneyfunctioninadultswithseveremotorandintellectualdisabilities
AT hasegawayuka evaluationofegfrstocalculatekidneyfunctioninadultswithseveremotorandintellectualdisabilities
AT nakashimahideaki evaluationofegfrstocalculatekidneyfunctioninadultswithseveremotorandintellectualdisabilities
AT otobeyoshihiro evaluationofegfrstocalculatekidneyfunctioninadultswithseveremotorandintellectualdisabilities