PC_ali: a tool for improved multiple alignments and evolutionary inference based on a hybrid protein sequence and structure similarity score

MOTIVATION: Evolutionary inference depends crucially on the quality of multiple sequence alignments (MSA), which is problematic for distantly related proteins. Since protein structure is more conserved than sequence, it seems natural to use structure alignments for distant homologs. However, structu...

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Detalles Bibliográficos
Autores principales: Bastolla, Ugo, Abia, David, Piette, Oscar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
Original Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10628387/
https://www.ncbi.nlm.nih.gov/pubmed/37847775
http://dx.doi.org/10.1093/bioinformatics/btad630

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10628387/
https://www.ncbi.nlm.nih.gov/pubmed/37847775
http://dx.doi.org/10.1093/bioinformatics/btad630

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