Cargando…
Tumor-targeted delivery of lnc antisense RNA against RCAS1 by live-attenuated tryptophan-auxotrophic Salmonella inhibited 4T1 breast tumors and metastasis in mice
Emerging chemo- and radiotherapy resistance exacerbated the cancer risk and necessitated novel treatment strategies. Although RNA therapeutics against pro-oncogenic genes are highly effective, tumor-specific delivery remains a barrier to the implementation of this valuable tool. In this study, we re...
Autores principales: | Sivasankar, Chandran, Hewawaduge, Chamith, Muthuramalingam, Pandiyan, Lee, John Hwa |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Society of Gene & Cell Therapy
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10628790/ https://www.ncbi.nlm.nih.gov/pubmed/37941832 http://dx.doi.org/10.1016/j.omtn.2023.102053 |
Ejemplares similares
-
Safety assessment of compliant, highly invasive, lipid A-altered, O-antigen-defected Salmonella strains as prospective vaccine delivery systems
por: Aganja, Ram Prasad, et al.
Publicado: (2022) -
Targeting primary and metastatic tumor growth in an aggressive breast cancer by engineered tryptophan auxotrophic Salmonella Typhimurium
por: Jawalagatti, Vijayakumar, et al.
Publicado: (2022) -
Salmonella-mediated oral delivery of multiple-target vaccine constructs with conserved and variable regions of SARS-CoV-2 protect against the Delta and Omicron variants in hamster
por: Lloren, Khristine Kaith Sison, et al.
Publicado: (2023) -
An mRNA-Based Multiple Antigenic Gene Expression System Delivered by Engineered Salmonella for Severe Fever with Thrombocytopenia Syndrome and Assessment of Its Immunogenicity and Protection Using a Human DC-SIGN-Transduced Mouse Model
por: Park, Ji-Young, et al.
Publicado: (2023) -
Live vaccine consisting of attenuated Salmonella secreting and delivering Brucella ribosomal protein L7/L12 induces humoral and cellular immune responses and protects mice against virulent Brucella abortus 544 challenge
por: Senevirathne, Amal, et al.
Publicado: (2020)