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Downregulation of 15-PGDH enhances MASH-HCC development via fatty acid-induced T-cell exhaustion
BACKGROUND & AIMS: Hepatocellular carcinoma (HCC) mainly develops from chronic hepatitis. Metabolic dysfunction-associated steatohepatitis (MASH) has gradually become the main pathogenic factor for HCC given the rising incidence of obesity and metabolic diseases. 15-Hydroxyprostaglandin dehydrog...
Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10628853/ https://www.ncbi.nlm.nih.gov/pubmed/37942226 http://dx.doi.org/10.1016/j.jhepr.2023.100892 |