Downregulation of 15-PGDH enhances MASH-HCC development via fatty acid-induced T-cell exhaustion

BACKGROUND & AIMS: Hepatocellular carcinoma (HCC) mainly develops from chronic hepatitis. Metabolic dysfunction-associated steatohepatitis (MASH) has gradually become the main pathogenic factor for HCC given the rising incidence of obesity and metabolic diseases. 15-Hydroxyprostaglandin dehydrog...

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Detalles Bibliográficos
Autores principales: Hu, Xichen, Yasuda, Tadahito, Yasuda-Yosihara, Noriko, Yonemura, Atsuko, Umemoto, Terumasa, Nakachi, Yutaka, Yamashita, Kohei, Semba, Takashi, Arima, Kota, Uchihara, Tomoyuki, Nishimura, Akiho, Bu, Luke, Fu, Lingfeng, Wei, Feng, Zhang, Jun, Tong, Yilin, Wang, Huaitao, Iwamoto, Kazuya, Fukuda, Takaichi, Nakagawa, Hayato, Taniguchi, Koji, Miyamoto, Yuji, Baba, Hideo, Ishimoto, Takatsugu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10628853/
https://www.ncbi.nlm.nih.gov/pubmed/37942226
http://dx.doi.org/10.1016/j.jhepr.2023.100892

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