PP121, a dual inhibitor of tyrosine and phosphoinositide kinases, relieves airway hyperresponsiveness, mucus hypersecretion and inflammation in a murine asthma model

BACKGROUND: Tyrosine kinase and phosphoinositide kinase pathways play important roles in asthma formation. As a dual tyrosine and phosphoinositide kinase inhibitor, PP121 has shown anticancer efficacy in multiple tumors. However, the study of PP121 in pulmonary diseases is still limited. Herein, we...

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Detalles Bibliográficos
Autores principales: Li, Wei, Xue, Lu, Peng, Changsi, Zhao, Ping, Peng, Yongbo, Chen, Weiwei, Wang, Wenyi, Shen, Jinhua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10629066/
https://www.ncbi.nlm.nih.gov/pubmed/37936054
http://dx.doi.org/10.1186/s10020-023-00748-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10629066/
https://www.ncbi.nlm.nih.gov/pubmed/37936054
http://dx.doi.org/10.1186/s10020-023-00748-w

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