Cargando…

PP121, a dual inhibitor of tyrosine and phosphoinositide kinases, relieves airway hyperresponsiveness, mucus hypersecretion and inflammation in a murine asthma model

BACKGROUND: Tyrosine kinase and phosphoinositide kinase pathways play important roles in asthma formation. As a dual tyrosine and phosphoinositide kinase inhibitor, PP121 has shown anticancer efficacy in multiple tumors. However, the study of PP121 in pulmonary diseases is still limited. Herein, we...

Descripción completa

Detalles Bibliográficos
Autores principales:	Li, Wei, Xue, Lu, Peng, Changsi, Zhao, Ping, Peng, Yongbo, Chen, Weiwei, Wang, Wenyi, Shen, Jinhua
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2023
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10629066/ https://www.ncbi.nlm.nih.gov/pubmed/37936054 http://dx.doi.org/10.1186/s10020-023-00748-w

Ejemplares similares

Lignosus rhinocerotis Cooke Ryvarden ameliorates airway inflammation, mucus hypersecretion and airway hyperresponsiveness in a murine model of asthma
por: Johnathan, Malagobadan, et al.
Publicado: (2021)

Association of the CFTR gene with asthma and airway mucus hypersecretion
por: Crespo-Lessmann, Astrid, et al.
Publicado: (2021)

Discovery of a drug to treat airway mucus hypersecretion
por: Dickey, Burton F., et al.
Publicado: (2022)

Azithromycin Inhibits Mucus Hypersecretion from Airway Epithelial Cells
por: Shimizu, Takeshi, et al.
Publicado: (2012)

Mucus Hypersecretion and Ciliary Impairment in Conducting Airway Contribute to Alveolar Mucus Plugging in Idiopathic Pulmonary Fibrosis
por: Peng, Yang, et al.
Publicado: (2022)

Clinical significance of airway mucus hypersecretion in chronic obstructive pulmonary disease
por: Tian, Pan-wen, et al.
Publicado: (2015)

Losartan reduces cigarette smoke-induced airway inflammation and mucus hypersecretion
por: Kim, Michael D., et al.
Publicado: (2021)

Lobeglitazone Attenuates Airway Inflammation and Mucus Hypersecretion in a Murine Model of Ovalbumin-Induced Asthma
por: Shin, Na-Rae, et al.
Publicado: (2018)

Bronchial Thermoplasty for Severe Asthma with Mucus Hypersecretion
por: Nagano, Naoko, et al.
Publicado: (2019)

Silver nanoparticles modify VEGF signaling pathway and mucus hypersecretion in allergic airway inflammation
por: Jang, Sunhyae, et al.
Publicado: (2012)

Neutrophil extracellular traps promote lipopolysaccharide-induced airway inflammation and mucus hypersecretion in mice
por: Zou, Yong, et al.
Publicado: (2018)

PPARγ as a Potential Target to Treat Airway Mucus Hypersecretion in Chronic Airway Inflammatory Diseases
por: Shen, Yongchun, et al.
Publicado: (2012)

Management of airway mucus hypersecretion in chronic airway inflammatory disease: Chinese expert consensus (English edition)
por: Shen, Yongchun, et al.
Publicado: (2018)

SARS-CoV-2–infected primary human airway epithelia illustrate mucus hypersecretion
por: Posch, Wilfried, et al.
Publicado: (2021)

Tbet Deficiency Causes T Helper Cell Dependent Airways Eosinophilia and Mucus Hypersecretion in Response to Rhinovirus Infection
por: Glanville, Nicholas, et al.
Publicado: (2016)

Potential Mechanisms for Traditional Chinese Medicine in Treating Airway Mucus Hypersecretion Associated With Coronavirus Disease 2019
por: Zhang, Yuanfeng, et al.
Publicado: (2020)

Therapeutic potential of Lianhua Qingke in airway mucus hypersecretion of acute exacerbation of chronic obstructive pulmonary disease
por: Hao, Yuanjie, et al.
Publicado: (2023)

Defining Chronic Mucus Hypersecretion Using the CAT in the SPIROMICS Cohort
por: Stott-Miller, Marni, et al.
Publicado: (2020)

Exacerbations of chronic obstructive pulmonary disease and chronic mucus hypersecretion
por: Tesfaigzi, Yohannes, et al.
Publicado: (2006)

Cytokine Storm and Mucus Hypersecretion in COVID-19: Review of Mechanisms
por: Khan, Mohsin Ali, et al.
Publicado: (2021)

Ciliary dyskinesia in severe asthma is not affected by chronic mucus hypersecretion
por: Kempeneers, Céline, et al.
Publicado: (2023)

Mucus Hypersecretion in Chronic Obstructive Pulmonary Disease and Its Treatment
por: Shah, Binay Kumar, et al.
Publicado: (2023)

Kaempferol Inhibits Endoplasmic Reticulum Stress-Associated Mucus Hypersecretion in Airway Epithelial Cells And Ovalbumin-Sensitized Mice
por: Park, Sin-Hye, et al.
Publicado: (2015)

β(2)-Adrenoceptor Involved in Smoking-Induced Airway Mucus Hypersecretion through β-Arrestin-Dependent Signaling
por: Zhou, Yujiao, et al.
Publicado: (2014)

Pneumocystis Exacerbates Inflammation and Mucus Hypersecretion in a Murine, Elastase-Induced-COPD Model
por: Rojas, Diego A., et al.
Publicado: (2023)

Susceptibility to Chronic Mucus Hypersecretion, a Genome Wide Association Study
por: Dijkstra, Akkelies E., et al.
Publicado: (2014)

ITGB4 deficiency induces mucus hypersecretion by upregulating MUC5AC in RSV-infected airway epithelial cells
por: Du, Xizi, et al.
Publicado: (2022)

Camellia sinensis (L.) Kuntze Extract Attenuates Ovalbumin-Induced Allergic Asthma by Regulating Airway Inflammation and Mucus Hypersecretion
por: Kang, Sohi, et al.
Publicado: (2023)

Blockade of Inflammation and Airway Hyperresponsiveness in Immune-sensitized Mice by Dominant-Negative Phosphoinositide 3-Kinase–TAT
por: Myou, Shigeharu, et al.
Publicado: (2003)

The novel compound Sul-121 inhibits airway inflammation and hyperresponsiveness in experimental models of chronic obstructive pulmonary disease
por: Han, Bing, et al.
Publicado: (2016)

Correction: Susceptibility to Chronic Mucus Hypersecretion, a Genome Wide Association Study
por: Dijkstra, Akkelies E., et al.
Publicado: (2015)

Tiotropium Bromide Attenuates Mucus Hypersecretion in Patients with Stable Chronic Obstructive Pulmonary Disease
por: Yu, Suyun, et al.
Publicado: (2021)

MicroRNAs Associated with Chronic Mucus Hypersecretion in COPD Are Involved in Fibroblast–Epithelium Crosstalk
por: Tasena, Hataitip, et al.
Publicado: (2022)

Amelioration of Cigarette Smoke-Induced Mucus Hypersecretion and Viscosity by Dendrobium officinale Polysaccharides In Vitro and In Vivo
por: Chen, Rui, et al.
Publicado: (2020)

Experimental Models of Airway Hyperresponsiveness
por: O'Byrne, Paul M., et al.
Publicado: (2005)

Curcumin Attenuates Asthmatic Airway Inflammation and Mucus Hypersecretion Involving a PPARγ-Dependent NF-κB Signaling Pathway In Vivo and In Vitro
por: Zhu, Tao, et al.
Publicado: (2019)

Effective-compound combination of Bufei Yishen formula III combined with ER suppress airway mucus hypersecretion in COPD rats: via EGFR/MAPK signaling
por: Xu, Kexin, et al.
Publicado: (2023)

Role of Abl in airway hyperresponsiveness and airway remodeling
por: Cleary, Rachel A, et al.
Publicado: (2013)

Dissociation by steroids of eosinophilic inflammation from airway hyperresponsiveness in murine airways
por: Birrell, Mark A, et al.
Publicado: (2003)

Lyn kinase represses mucus hypersecretion by regulating IL-13-induced endoplasmic reticulum stress in asthma
por: Wang, Xing, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_q8fdepsla6cm8k9japto2lqhs7