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PCBP1 regulates LIFR through FAM3C to maintain breast cancer stem cell self-renewal and invasiveness

The poly(rC) binding protein 1 gene (PCBP1) encodes the heterogeneous nuclear ribonucleoprotein E1 (hnRNPE1), a nucleic acid-binding protein that plays a tumor-suppressive role in the mammary epithelium by regulating phenotypic plasticity and cell fate. Following the loss of PCBP1 function, the FAM3...

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Detalles Bibliográficos
Autores principales: Streitfeld, William S., Dalton, Annamarie C., Howley, Breege V., Howe, Philip H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10629429/
https://www.ncbi.nlm.nih.gov/pubmed/37927213
http://dx.doi.org/10.1080/15384047.2023.2271638