Cargando…

PCBP1 regulates LIFR through FAM3C to maintain breast cancer stem cell self-renewal and invasiveness

The poly(rC) binding protein 1 gene (PCBP1) encodes the heterogeneous nuclear ribonucleoprotein E1 (hnRNPE1), a nucleic acid-binding protein that plays a tumor-suppressive role in the mammary epithelium by regulating phenotypic plasticity and cell fate. Following the loss of PCBP1 function, the FAM3...

Descripción completa

Detalles Bibliográficos
Autores principales:	Streitfeld, William S., Dalton, Annamarie C., Howley, Breege V., Howe, Philip H.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Taylor & Francis 2023
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10629429/ https://www.ncbi.nlm.nih.gov/pubmed/37927213 http://dx.doi.org/10.1080/15384047.2023.2271638

Ejemplares similares

TGFβ promotes breast cancer stem cell self-renewal through an ILEI/LIFR signaling axis
por: Woosley, Alec N., et al.
Publicado: (2019)

The ubiquitin E3 ligase ARIH1 regulates hnRNP E1 protein stability, EMT and breast cancer progression
por: Howley, Breege V., et al.
Publicado: (2022)

Heterogeneous nuclear ribonucleoprotein E1 binds polycytosine DNA and monitors genome integrity
por: Mohanty, Bidyut K, et al.
Publicado: (2021)

TGFβ-induced expression of long noncoding lincRNA Platr18 controls breast cancer axonogenesis
por: Grelet, Simon, et al.
Publicado: (2021)

Interleukin-like EMT inducer (ILEI) promotes melanoma invasiveness and is transcriptionally up-regulated by upstream stimulatory factor-1 (USF-1)
por: Noguchi, Ken, et al.
Publicado: (2018)

Interleukin-like EMT inducer regulates partial phenotype switching in MITF-low melanoma cell lines
por: Noguchi, Ken, et al.
Publicado: (2017)

FAM129A promotes self-renewal and maintains invasive status via stabilizing the Notch intracellular domain in glioma stem cells
por: Liu, Guohao, et al.
Publicado: (2023)

Metastasis-associated upregulation of ER-Golgi trafficking kinetics: regulation of cancer progression via the Golgi apparatus
por: Howley, Breege V., et al.
Publicado: (2018)

Translational regulation of Inhibin βA by TGFβ via the RNA-binding protein hnRNP E1 enhances the invasiveness of epithelial-to-mesenchymal transitioned cells
por: Howley, Breege V, et al.
Publicado: (2015)

Post-transcriptional mapping reveals critical regulators of metastasis
por: Hussey, George S., et al.
Publicado: (2015)

Targeting LIF/LIFR signaling in cancer
por: Viswanadhapalli, Suryavathi, et al.
Publicado: (2021)

A CREB3-regulated ER-Golgi trafficking signature promotes metastatic progression in breast cancer
por: Howley, Breege V, et al.
Publicado: (2017)

Nrf2 is required to maintain the self-renewal of glioma stem cells
por: Zhu, Jianhong, et al.
Publicado: (2013)

BPTF Maintains Chromatin Accessibility and the Self-Renewal Capacity of Mammary Gland Stem Cells
por: Frey, Wesley D., et al.
Publicado: (2017)

Establishment of a TGFβ-Induced Post-Transcriptional EMT Gene Signature
por: Hussey, George S., et al.
Publicado: (2012)

Correction to: Nrf2 is required to maintain the self-renewal of glioma stem cells
por: Zhu, Jianhong, et al.
Publicado: (2021)

Inhibition of LIFR Blocks Adiposity-Driven Endometrioid Endometrial Cancer Growth
por: Blankenship, Logan, et al.
Publicado: (2022)

Porphyrin Homeostasis Maintained by ABCG2 Regulates Self-Renewal of Embryonic Stem Cells
por: Susanto, Jimmy, et al.
Publicado: (2008)

GRK6 regulates ROS response and maintains hematopoietic stem cell self-renewal
por: Le, Qiumin, et al.
Publicado: (2016)

c-Myc maintains the self-renewal and chemoresistance properties of colon cancer stem cells
por: Zhang, Huan-Le, et al.
Publicado: (2019)

HCK maintains the self-renewal of leukaemia stem cells via CDK6 in AML
por: Li, Zheng, et al.
Publicado: (2021)

Alkbh5 plays indispensable roles in maintaining self-renewal of hematopoietic stem cells
por: Yang, Bijie, et al.
Publicado: (2023)

lncRNA PCBP1-AS1 Aggravates the Progression of Hepatocellular Carcinoma via Regulating PCBP1/PRL-3/AKT Pathway
por: Luo, Tianping, et al.
Publicado: (2020)

PCBP2 maintains antiviral signaling homeostasis by regulating cGAS enzymatic activity via antagonizing its condensation
por: Gu, Haiyan, et al.
Publicado: (2022)

Nucleostemin maintains self-renewal of embryonic stem cells and promotes reprogramming of somatic cells to pluripotency
por: Qu, Jian, et al.
Publicado: (2012)

Sp5 induces the expression of Nanog to maintain mouse embryonic stem cell self-renewal
por: Tang, Ling, et al.
Publicado: (2017)

Depletion of Tcf3 and Lef1 maintains mouse embryonic stem cell self-renewal
por: Ye, Shoudong, et al.
Publicado: (2017)

RNA binding protein SYNCRIP maintains proteostasis and self-renewal of hematopoietic stem and progenitor cells
por: Herrejon Chavez, Florisela, et al.
Publicado: (2023)

LIF/LIFR oncogenic signaling is a novel therapeutic target in endometrial cancer
por: Tang, Weiwei, et al.
Publicado: (2021)

Hair follicle stem cells regulate retinoid metabolism to maintain the self-renewal niche for melanocyte stem cells
por: Lu, Zhiwei, et al.
Publicado: (2020)

Stüve-Wiedemann syndrome: LIFR and associated cytokines in clinical course and etiology
por: Mikelonis, Dawn, et al.
Publicado: (2014)

RNA binding protein PCBP1 is an intracellular immune checkpoint for shaping T cell responses in cancer immunity
por: Ansa-Addo, Ephraim A., et al.
Publicado: (2020)

Correction: PCBP1 and PCBP2 both bind heavily oxidized RNA but cause opposing outcomes, suppressing or increasing apoptosis under oxidative conditions
por: Ishii, Takashi, et al.
Publicado: (2021)

LIFR inhibition enhances the therapeutic efficacy of HDAC inhibitors in triple negative breast cancer
por: Li, Mengxing, et al.
Publicado: (2021)

HDAC inhibitors induce LIFR expression and promote a dormancy phenotype in breast cancer
por: Clements, Miranda E., et al.
Publicado: (2021)

Interplay between PCBP2 and miRNA modulates ARHGDIA expression and function in glioma migration and invasion
por: Lin, Xihua, et al.
Publicado: (2016)

Self-Renewal of Stem Cells
por: Terskikh, V.V., et al.
Publicado: (2009)

Dynamics and energetics of PCBP1 binding to severely oxidized RNA
por: Gillet, Natacha, et al.
Publicado: (2022)

RARγ is critical for maintaining a balance between hematopoietic stem cell self-renewal and differentiation
por: Purton, Louise E., et al.
Publicado: (2006)

Ethanol Inactivated Mouse Embryonic Fibroblasts Maintain the Self-Renew and Proliferation of Human Embryonic Stem Cells
por: Huang, Boxian, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_t77vqa2vbsuvsj7rtregiiqi42