Flavivirus genome recoding by codon optimisation confers genetically stable in vivo attenuation in both mice and mosquitoes

Virus genome recoding is an attenuation method that confers genetically stable attenuation by rewriting a virus genome with numerous silent mutations. Prior flavivirus genome recoding attempts utilised codon deoptimisation approaches. However, these codon deoptimisation approaches act in a species d...

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Detalles Bibliográficos
Autores principales: Chin, Wei-Xin, Kong, Hao Yuin, Zhu, Isabelle Xin Yu, Teo, Zi Yun, Faruk, Regina, Lee, Regina Ching Hua, Ho, Si Xian, Aw, Zhen Qin, Yi, Bowen, Hou, Xin Jun, Tan, Antson Kiat Yee, Yogarajah, Thinesshwary, Huber, Roland G., Cai, Yu, Wan, Yue, Chu, Justin Jang Hann
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10629665/
https://www.ncbi.nlm.nih.gov/pubmed/37883598
http://dx.doi.org/10.1371/journal.ppat.1011753

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10629665/
https://www.ncbi.nlm.nih.gov/pubmed/37883598
http://dx.doi.org/10.1371/journal.ppat.1011753

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