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Flavivirus genome recoding by codon optimisation confers genetically stable in vivo attenuation in both mice and mosquitoes
Virus genome recoding is an attenuation method that confers genetically stable attenuation by rewriting a virus genome with numerous silent mutations. Prior flavivirus genome recoding attempts utilised codon deoptimisation approaches. However, these codon deoptimisation approaches act in a species d...
| Autores principales: | , , , , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Public Library of Science
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10629665/ https://www.ncbi.nlm.nih.gov/pubmed/37883598 http://dx.doi.org/10.1371/journal.ppat.1011753 |