Pharmacological inhibition of bromodomain and extra-terminal proteins induces an NRF-2-mediated antiviral state that is subverted by SARS-CoV-2 infection

Inhibitors of bromodomain and extra-terminal proteins (iBETs), including JQ-1, have been suggested as potential prophylactics against SARS-CoV-2 infection. However, molecular mechanisms underlying JQ-1-mediated antiviral activity and its susceptibility to viral subversion remain incompletely underst...

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Detalles Bibliográficos
Autores principales: Mhlekude, Baxolele, Postmus, Dylan, Stenzel, Saskia, Weiner, January, Jansen, Jenny, Zapatero-Belinchón, Francisco J., Olmer, Ruth, Richter, Anja, Heinze, Julian, Heinemann, Nicolas, Mühlemann, Barbara, Schroeder, Simon, Jones, Terry C., Müller, Marcel A., Drosten, Christian, Pich, Andreas, Thiel, Volker, Martin, Ulrich, Niemeyer, Daniela, Gerold, Gisa, Beule, Dieter, Goffinet, Christine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10629670/
https://www.ncbi.nlm.nih.gov/pubmed/37747932
http://dx.doi.org/10.1371/journal.ppat.1011657

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10629670/
https://www.ncbi.nlm.nih.gov/pubmed/37747932
http://dx.doi.org/10.1371/journal.ppat.1011657

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