Endothelial cell SMAD6 balances Alk1 function to regulate adherens junctions and hepatic vascular development

BMP signaling is crucial to blood vessel formation and function, but how pathway components regulate vascular development is not well-understood. Here, we find that inhibitory SMAD6 functions in endothelial cells to negatively regulate ALK1-mediated responses, and it is required to prevent vessel dy...

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Detalles Bibliográficos
Autores principales: Kulikauskas, Molly R., Oatley, Morgan, Yu, Tianji, Liu, Ziqing, Matsumura, Lauren, Kidder, Elise, Ruter, Dana, Bautch, Victoria L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists Ltd 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10629679/
https://www.ncbi.nlm.nih.gov/pubmed/37787089
http://dx.doi.org/10.1242/dev.201811

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10629679/
https://www.ncbi.nlm.nih.gov/pubmed/37787089
http://dx.doi.org/10.1242/dev.201811

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