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C-terminal modification and functionalization of proteins via a self-cleavage tag triggered by a small molecule
The precise modification or functionalization of the protein C-terminus is essential but full of challenges. Herein, a chemical approach to modify the C-terminus is developed by fusing a cysteine protease domain on the C-terminus of the protein of interest, which could achieve the non-enzymatic C-te...
| Autores principales: | , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10630284/ https://www.ncbi.nlm.nih.gov/pubmed/37935692 http://dx.doi.org/10.1038/s41467-023-42977-x |