Real-time monitoring of the reaction of KRAS G12C mutant specific covalent inhibitor by in vitro and in-cell NMR spectroscopy

KRAS mutations are major drivers of various cancers. Recently, allele-specific inhibitors of the KRAS G12C mutant were developed that covalently modify the thiol of Cys12, thereby trapping KRAS in an inactive GDP-bound state. To study the mechanism of action of the covalent inhibitors in both in vit...

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Detalles Bibliográficos
Autores principales: Zhao, Qingci, Haga, Ryoka, Tamura, Satoko, Shimada, Ichio, Nishida, Noritaka
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10630485/
https://www.ncbi.nlm.nih.gov/pubmed/37935773
http://dx.doi.org/10.1038/s41598-023-46623-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10630485/
https://www.ncbi.nlm.nih.gov/pubmed/37935773
http://dx.doi.org/10.1038/s41598-023-46623-w

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