Pyruvate dehydrogenase kinase 1 protects against neuronal injury and memory loss in mouse models of diabetes

Hyperglycemia-induced aberrant glucose metabolism is a causative factor of neurodegeneration and cognitive impairment in diabetes mellitus (DM) patients. The pyruvate dehydrogenase kinase (PDK)–lactic acid axis is regarded as a critical link between metabolic reprogramming and the pathogenic process...

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Detalles Bibliográficos
Autores principales: Yao, Yuan, Shi, Jiaming, Zhang, Chunlai, Gao, Wei, Huang, Ning, Liu, Yaobei, Yan, Weiwen, Han, Yingguang, Zhou, Wenjuan, Kong, Liang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10630521/
https://www.ncbi.nlm.nih.gov/pubmed/37935660
http://dx.doi.org/10.1038/s41419-023-06249-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10630521/
https://www.ncbi.nlm.nih.gov/pubmed/37935660
http://dx.doi.org/10.1038/s41419-023-06249-2

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