Cargando…

Effective Treatment of SSTR2-Positive Small Cell Lung Cancer Using (211)At-Containing Targeted α-Particle Therapy Agent Which Promotes Endogenous Antitumor Immune Response

[Image: see text] Small cell lung cancer (SCLC) is a neuroendocrine tumor with a high degree of malignancy. Due to limited treatment options, patients with SCLC have a poor prognosis. We have found, however, that intravenously administered octreotide (Oct) armed with astatine-211 ([(211)At]SAB-Oct)...

Descripción completa

Detalles Bibliográficos
Autores principales:	Qin, Shanshan, Yang, Yuanyou, Zhang, Jiajia, Yin, Yuzhen, Liu, Weihao, Zhang, Han, Fan, Xin, Yang, Mengdie, Yu, Fei
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2023
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10630944/ https://www.ncbi.nlm.nih.gov/pubmed/37788300 http://dx.doi.org/10.1021/acs.molpharmaceut.3c00427

Ejemplares similares

Alpha radionuclide-chelated radioimmunotherapy promoters enable local radiotherapy/chemodynamic therapy to discourage cancer progression
por: Zhang, Jiajia, et al.
Publicado: (2022)

Construction and Preclinical Evaluation of (211)At Labeled Anti-mesothelin Antibodies as Potential Targeted Alpha Therapy Drugs
por: Wang, Xudong, et al.
Publicado: (2020)

mRNA expression of somatostatin receptor subtypes SSTR-2, SSTR-3, and SSTR-5 and its significance in pancreatic cancer
por: Shahbaz, Muhammad, et al.
Publicado: (2015)

The effect of strength and endurance training on SSTR2 and SSTR5 in patients with colorectal cancer
por: Zanjani, Farhad Safari, et al.
Publicado: (2019)

Expression of Somatostatin Receptor Subtypes (SSTR-1–SSTR-5) in Pediatric Hematological and Oncological Disorders
por: Harda, Kristof, et al.
Publicado: (2020)

Coexpression of human somatostatin receptor-2 (SSTR2) and SSTR3 modulates antiproliferative signaling and apoptosis
por: War, Sajad A, et al.
Publicado: (2012)

Comparing the use of radiolabeled SSTR agonists and an SSTR antagonist in breast cancer: does the model choice influence the outcome?
por: Dalm, Simone U., et al.
Publicado: (2017)

Gold Nanostars: A Novel Platform for Developing (211)At-Labeled Agents for Targeted Alpha-Particle Therapy
por: Liu, Yang, et al.
Publicado: (2021)

Clinical Importance of Somatostatin Receptor 2 (SSTR2) and Somatostatin Receptor 5 (SSTR5) Expression in Thyrotropin-Producing Pituitary Adenoma (TSHoma)
por: Yu, Benxia, et al.
Publicado: (2017)

Preclinical Development of [(211)At]meta- astatobenzylguanidine ([(211)At]MABG) as an Alpha Particle Radiopharmaceutical Therapy for Neuroblastoma
por: Batra, Vandana, et al.
Publicado: (2022)

Texture Analysis of (18)F-FDG PET/CT for Differential Diagnosis Spinal Metastases
por: Fan, Xin, et al.
Publicado: (2021)

Validation of the SSTR-RADS 1.0 for the structured interpretation of SSTR-PET/CT and treatment planning in neuroendocrine tumor (NET) patients
por: Grawe, Freba, et al.
Publicado: (2023)

Retracted: Clinical Importance of Somatostatin Receptor 2 (SSTR2) and Somatostatin Receptor 5 (SSTR5) Expression in Thyrotropin-Producing Pituitary Adenoma (TSHoma)
por: Song, Hao, et al.
Publicado: (2018)

Novel Azetidine-Containing TZT-1027 Analogues as Antitumor Agents
por: Yan, Qi, et al.
Publicado: (2016)

Clinical Significance of Somatostatin Receptor (SSTR) 2 in Meningioma
por: Wu, Wei, et al.
Publicado: (2020)

Molecular simulations of SSTR2 dynamics and interaction with ligands
por: Gervasoni, Silvia, et al.
Publicado: (2023)

Immunogenic Cell Death Induction by Ionizing Radiation
por: Zhu, Mengqin, et al.
Publicado: (2021)

Childhood Adversities are not a Predictors of SSTR4met in Alcoholics
por: Berent, Dominika, et al.
Publicado: (2017)

Expression of Somatostatin Receptor (SSTR) Subtypes (SSTR-1, 2A, 3, 4 and 5) in Neuroendocrine Tumors Using Real-time RT-PCR Method and Immunohistochemistry
por: Mizutani, Gou, et al.
Publicado: (2012)

SSTR4, Childhood Adversity, Self-efficacy and Suicide Risk in Alcoholics
por: Berent, Dominika, et al.
Publicado: (2017)

Somatostatin receptors (SSTR1-5) on inhibitory interneurons in the barrel cortex
por: Lukomska, Agnieszka, et al.
Publicado: (2019)

Anti-SSTR2 Antibody-drug Conjugate for Neuroendocrine Tumor Therapy
por: Si, Yingnan, et al.
Publicado: (2020)

Differences in the expression of SSTR1–5 in meningiomas and its therapeutic potential
por: Behling, Felix, et al.
Publicado: (2021)

Molecular Imaging of Vulnerable Coronary Plaque with Radiolabeled Somatostatin Receptors (SSTR)
por: Anzola, Luz Kelly, et al.
Publicado: (2021)

The immunohistochemical expression of SSTR2A is an independent prognostic factor in meningioma
por: Fodi, Christina, et al.
Publicado: (2021)

Properties of $^{211}_{85}$At$_{126}$ as observed in the decay of $^{211}$Rn
por: Astner, G
Publicado: (1972)

Biomimetic radiosensitizers unlock radiogenetics for local interstitial radiotherapy to activate systematic immune responses and resist tumor metastasis
por: Zhang, Jiajia, et al.
Publicado: (2022)

Evidence of Local Concentration of α-Particles from (211)At-Labeled Antibodies in Liver Metastasis Tissue
por: Kodaira, Satoshi, et al.
Publicado: (2019)

Identification of SSTR5 Gene Polymorphisms and Their Association With Growth Traits in Hulun Buir Sheep
por: Li, Xue, et al.
Publicado: (2022)

Antitumor effects of radionuclide treatment using α-emitting meta-(211)At-astato-benzylguanidine in a PC12 pheochromocytoma model
por: Ohshima, Yasuhiro, et al.
Publicado: (2018)

Hydroxide-Mediated S(N)Ar Rearrangement for Synthesis of Novel Depside Derivatives Containing Diaryl Ether Skeleton as Antitumor Agents
por: Yu, Xiang, et al.
Publicado: (2023)

ZAC1 and SSTR2 Are Downregulated in Non-Functioning Pituitary Adenomas but Not in somatotropinomas
por: Vieria Neto, Leonardo, et al.
Publicado: (2013)

SSTR2A expression in medullary thyroid carcinoma is correlated with longer survival
por: de Vries, Lisa H., et al.
Publicado: (2018)

Correction to: The immunohistochemical expression of SSTR2A is an independent prognostic factor in meningioma
por: Fodi, Christina, et al.
Publicado: (2022)

Beta cell primary cilia mediate somatostatin responsiveness via SSTR3
por: Adamson, Samantha E., et al.
Publicado: (2023)

Human dosimetry of free (211)At and meta-[(211)At]astatobenzylguanidine ((211)At-MABG) estimated using preclinical biodistribution from normal mice
por: Ukon, Naoyuki, et al.
Publicado: (2020)

Protection from contamination by (211)At, an enigmatic but promising alpha-particle-emitting radionuclide
por: Ohnuki, Kazunobu, et al.
Publicado: (2022)

Novel Coumarin-Containing Aminophosphonatesas Antitumor Agent: Synthesis, Cytotoxicity, DNA-Binding and Apoptosis Evaluation
por: Li, Ya-Jun, et al.
Publicado: (2015)

Astatine-211-Labeled Gold Nanoparticles for Targeted Alpha-Particle Therapy via Intravenous Injection
por: Huang, Xuhao, et al.
Publicado: (2022)

Airway surface liquid contains endogenous DNase activity which can be activated by exogenous magnesium
por: Rosenecker, J, et al.
Publicado: (2009)

Cannot write session to /tmp/vufind_sessions/sess_7u6chsf7cq9jfb5amcmc0n0gug