Dissimilar Effect of P-Glycoprotein and Breast Cancer Resistance Protein Inhibition on the Distribution of Erlotinib to the Retina and Brain in Humans and Mice

[Image: see text] P-glycoprotein (P-gp) and breast cancer resistance protein (BCRP) are two ATP-binding cassette efflux transporters that are coexpressed at the human blood–brain barrier (BBB) and blood–retina barrier (BRB). While pharmacological inhibition of P-gp and/or BCRP results in increased b...

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Detalles Bibliográficos
Autores principales: Biali, Myriam El, Auvity, Sylvain, Cisternino, Salvatore, Smirnova, Maria, Hacker, Marcus, Zeitlinger, Markus, Mairinger, Severin, Tournier, Nicolas, Bauer, Martin, Langer, Oliver
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10630959/
https://www.ncbi.nlm.nih.gov/pubmed/37883694
http://dx.doi.org/10.1021/acs.molpharmaceut.3c00715

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10630959/
https://www.ncbi.nlm.nih.gov/pubmed/37883694
http://dx.doi.org/10.1021/acs.molpharmaceut.3c00715

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