Impact of library input on the hit discovery rate in DNA-encoded chemical library selections

DNA-encoded chemical libraries (DELs) are powerful drug discovery tools, enabling the parallel screening of millions of DNA-barcoded compounds. We investigated how the DEL input affects the hit discovery rate in DEL screenings. Evaluation of selection fingerprints revealed that the use of approximat...

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Detalles Bibliográficos
Autores principales: Puglioli, Sara, Oehler, Sebastian, Prati, Luca, Scheuermann, Jörg, Bassi, Gabriele, Cazzamalli, Samuele, Neri, Dario, Favalli, Nicholas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2023
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10631129/
https://www.ncbi.nlm.nih.gov/pubmed/37969600
http://dx.doi.org/10.1039/d3sc03688j

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10631129/
https://www.ncbi.nlm.nih.gov/pubmed/37969600
http://dx.doi.org/10.1039/d3sc03688j

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