Structure-guided optimisation of N-hydroxythiazole-derived inhibitors of factor inhibiting hypoxia-inducible factor-α

The human 2-oxoglutarate (2OG)- and Fe(ii)-dependent oxygenases factor inhibiting hypoxia-inducible factor-α (FIH) and HIF-α prolyl residue hydroxylases 1–3 (PHD1–3) regulate the response to hypoxia in humans via catalysing hydroxylation of the α-subunits of the hypoxia-inducible factors (HIFs). Sma...

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Detalles Bibliográficos
Autores principales: Corner, Thomas P., Teo, Ryan Z. R., Wu, Yue, Salah, Eidarus, Nakashima, Yu, Fiorini, Giorgia, Tumber, Anthony, Brasnett, Amelia, Holt-Martyn, James P., Figg, William D., Zhang, Xiaojin, Brewitz, Lennart, Schofield, Christopher J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2023
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10631261/
https://www.ncbi.nlm.nih.gov/pubmed/37969593
http://dx.doi.org/10.1039/d3sc04253g

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10631261/
https://www.ncbi.nlm.nih.gov/pubmed/37969593
http://dx.doi.org/10.1039/d3sc04253g

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