Role of affinity in plasma cell development in the germinal center light zone

Protective immune responses to many pathogens depend on the development of high-affinity antibody-producing plasma cells (PC) in germinal centers (GCs). Transgenic models suggest that there is a stringent affinity-based barrier to PC development. Whether a similar high-affinity barrier regulates PC...

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Detalles Bibliográficos
Autores principales: ElTanbouly, Mohamed A., Ramos, Victor, MacLean, Andrew J., Chen, Spencer T., Loewe, Maximilian, Steinbach, Sandra, Ben Tanfous, Tarek, Johnson, Brianna, Cipolla, Melissa, Gazumyan, Anna, Oliveira, Thiago Y., Nussenzweig, Michel C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10631489/
https://www.ncbi.nlm.nih.gov/pubmed/37938344
http://dx.doi.org/10.1084/jem.20231838

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10631489/
https://www.ncbi.nlm.nih.gov/pubmed/37938344
http://dx.doi.org/10.1084/jem.20231838

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