Acute inhibition of acid sensing ion channel 1a after spinal cord injury selectively affects excitatory synaptic transmission, but not intrinsic membrane properties, in deep dorsal horn interneurons

Following a spinal cord injury (SCI), secondary damage mechanisms are triggered that cause inflammation and cell death. A key component of this secondary damage is a reduction in local blood flow that initiates a well-characterised ischemic cascade. Downstream hypoxia and acidosis activate acid sens...

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Detalles Bibliográficos
Autores principales: Foster, Victoria S., Saez, Natalie, King, Glenn F., Rank, Michelle M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10631665/
https://www.ncbi.nlm.nih.gov/pubmed/37939057
http://dx.doi.org/10.1371/journal.pone.0289053

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10631665/
https://www.ncbi.nlm.nih.gov/pubmed/37939057
http://dx.doi.org/10.1371/journal.pone.0289053

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