Human virome profiling identified CMV as the major viral driver of a high accumulation of senescent CD8(+) T cells in patients with advanced NSCLC

Circulating senescent CD8(+) T (T(8)sen) cells are characterized by a lack of proliferative capacities but retain cytotoxic activity and have been associated to resistance to immunotherapy in patients with advanced non–small cell lung cancer (aNSCLC). We aimed to better characterize T(8)sen and to d...

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Detalles Bibliográficos
Autores principales: Naigeon, Marie, Roulleaux Dugage, Matthieu, Danlos, François-Xavier, Boselli, Lisa, Jouniaux, Jean-Mehdi, de Oliveira, Caroline, Ferrara, Roberto, Duchemann, Boris, Berthot, Caroline, Girard, Lou, Flippot, Ronan, Albiges, Laurence, Farhane, Siham, Saulnier, Patrick, Lacroix, Ludovic, Griscelli, Frank, Roman, Gabriel, Hulett, Tyler, Marabelle, Aurélien, Cassard, Lydie, Besse, Benjamin, Chaput, Nathalie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2023
Materias:
Biomedicine and Life Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10631735/
https://www.ncbi.nlm.nih.gov/pubmed/37939189
http://dx.doi.org/10.1126/sciadv.adh0708

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10631735/
https://www.ncbi.nlm.nih.gov/pubmed/37939189
http://dx.doi.org/10.1126/sciadv.adh0708

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