Mosaic chromosomal alterations in blood across ancestries using whole-genome sequencing

Megabase-scale mosaic chromosomal alterations (mCAs) in blood are prognostic markers for a host of human diseases. Here, to gain a better understanding of mCA rates in genetically diverse populations, we analyzed whole-genome sequencing data from 67,390 individuals from the National Heart, Lung, and...

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Detalles Bibliográficos
Autores principales: Jakubek, Yasminka A., Zhou, Ying, Stilp, Adrienne, Bacon, Jason, Wong, Justin W., Ozcan, Zuhal, Arnett, Donna, Barnes, Kathleen, Bis, Joshua C., Boerwinkle, Eric, Brody, Jennifer A., Carson, April P., Chasman, Daniel I., Chen, Jiawen, Cho, Michael, Conomos, Matthew P., Cox, Nancy, Doyle, Margaret F., Fornage, Myriam, Guo, Xiuqing, Kardia, Sharon L. R., Lewis, Joshua P., Loos, Ruth J. F., Ma, Xiaolong, Machiela, Mitchell J., Mack, Taralynn M., Mathias, Rasika A., Mitchell, Braxton D., Mychaleckyj, Josyf C., North, Kari, Pankratz, Nathan, Peyser, Patricia A., Preuss, Michael H., Psaty, Bruce, Raffield, Laura M., Vasan, Ramachandran S., Redline, Susan, Rich, Stephen S., Rotter, Jerome I., Silverman, Edwin K., Smith, Jennifer A., Smith, Aaron P., Taub, Margaret, Taylor, Kent D., Yun, Jeong, Li, Yun, Desai, Pinkal, Bick, Alexander G., Reiner, Alexander P., Scheet, Paul, Auer, Paul L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group US 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10632132/
https://www.ncbi.nlm.nih.gov/pubmed/37904051
http://dx.doi.org/10.1038/s41588-023-01553-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10632132/
https://www.ncbi.nlm.nih.gov/pubmed/37904051
http://dx.doi.org/10.1038/s41588-023-01553-1

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