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Age-dependent topic modeling of comorbidities in UK Biobank identifies disease subtypes with differential genetic risk
The analysis of longitudinal data from electronic health records (EHRs) has the potential to improve clinical diagnoses and enable personalized medicine, motivating efforts to identify disease subtypes from patient comorbidity information. Here we introduce an age-dependent topic modeling (ATM) meth...
Autores principales: | Jiang, Xilin, Zhang, Martin Jinye, Zhang, Yidong, Durvasula, Arun, Inouye, Michael, Holmes, Chris, Price, Alkes L., McVean, Gil |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group US
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10632146/ https://www.ncbi.nlm.nih.gov/pubmed/37814053 http://dx.doi.org/10.1038/s41588-023-01522-8 |
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