Mechanism of selective recognition of Lys48-linked polyubiquitin by macrocyclic peptide inhibitors of proteasomal degradation

Post-translational modification of proteins with polyubiquitin chains is a critical cellular signaling mechanism in eukaryotes with implications in various cellular states and processes. Unregulated ubiquitin-mediated protein degradation can be detrimental to cellular homeostasis, causing numerous d...

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Detalles Bibliográficos
Autores principales: Lemma, Betsegaw, Zhang, Di, Vamisetti, Ganga B., Wentz, Bryan G., Suga, Hiroaki, Brik, Ashraf, Lubkowski, Jacek, Fushman, David
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10632358/
https://www.ncbi.nlm.nih.gov/pubmed/37938554
http://dx.doi.org/10.1038/s41467-023-43025-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10632358/
https://www.ncbi.nlm.nih.gov/pubmed/37938554
http://dx.doi.org/10.1038/s41467-023-43025-4

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