A novel in silico scaffold-hopping method for drug repositioning in rare and intractable diseases

In the field of rare and intractable diseases, new drug development is difficult and drug repositioning (DR) is a key method to improve this situation. In this study, we present a new method for finding DR candidates utilizing virtual screening, which integrates amino acid interaction mapping into s...

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Detalles Bibliográficos
Autores principales: Tanabe, Mao, Sakate, Ryuichi, Nakabayashi, Jun, Tsumura, Kyosuke, Ohira, Shino, Iwato, Kaoru, Kimura, Tomonori
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10632405/
https://www.ncbi.nlm.nih.gov/pubmed/37938624
http://dx.doi.org/10.1038/s41598-023-46648-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10632405/
https://www.ncbi.nlm.nih.gov/pubmed/37938624
http://dx.doi.org/10.1038/s41598-023-46648-1

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