Antifibrotic effect of apremilast in systemic sclerosis dermal fibroblasts and bleomycin-induced mouse model

Phosphodiesterase (PDE) 4 inhibitors have been reported to suppress the progression of dermal fibrosis in patients with systemic sclerosis (SSc); however, the precise mechanisms remain to be elucidated. Therefore, we conducted experiments focusing on the antifibrotic and anti-inflammatory effects of...

Descripción completa

Detalles Bibliográficos
Autores principales: Higuchi, Tomoaki, Takagi, Kae, Tochimoto, Akiko, Ichimura, Yuki, Hirose, Hikaru, Sawada, Tatsuo, Shibata, Noriyuki, Harigai, Masayoshi, Kawaguchi, Yasushi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10632419/
https://www.ncbi.nlm.nih.gov/pubmed/37938601
http://dx.doi.org/10.1038/s41598-023-46737-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10632419/
https://www.ncbi.nlm.nih.gov/pubmed/37938601
http://dx.doi.org/10.1038/s41598-023-46737-1

Ejemplares similares