Asymmetric conformations and lipid interactions shape the ATP-coupled cycle of a heterodimeric ABC transporter

Here we used cryo-electron microscopy (cryo-EM), double electron-electron resonance spectroscopy (DEER), and molecular dynamics (MD) simulations, to capture and characterize ATP- and substrate-bound inward-facing (IF) and occluded (OC) conformational states of the heterodimeric ATP binding cassette...

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Detalles Bibliográficos
Autores principales: Tang, Qingyu, Sinclair, Matt, Hasdemir, Hale S., Stein, Richard A., Karakas, Erkan, Tajkhorshid, Emad, Mchaourab, Hassane S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10632425/
https://www.ncbi.nlm.nih.gov/pubmed/37938578
http://dx.doi.org/10.1038/s41467-023-42937-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10632425/
https://www.ncbi.nlm.nih.gov/pubmed/37938578
http://dx.doi.org/10.1038/s41467-023-42937-5

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