IL6 suppresses vaccine responses in neonates by enhancing IL2 activity on T follicular helper cells

The inability of neonates to develop CD4(+)FoxP3(-)CXCR5(hi)PD-1(hi) T follicular helper (T(FH)) cells contributes to their weak vaccine responses. In previous studies, we measured diminished IgG responses when IL-6 was co-injected with a pneumococcal conjugate vaccine (PCV) in neonatal mice. This i...

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Detalles Bibliográficos
Autores principales: Parvathaneni, Swetha, Yang, Jiyeon, Lotspeich-Cole, Leda, Sakai, Jiro, Lee, Robert C., Akkoyunlu, Mustafa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10632457/
https://www.ncbi.nlm.nih.gov/pubmed/37938563
http://dx.doi.org/10.1038/s41541-023-00764-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10632457/
https://www.ncbi.nlm.nih.gov/pubmed/37938563
http://dx.doi.org/10.1038/s41541-023-00764-1

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