Inadequate structural constraint on Fab approach rather than paratope elicitation limits HIV-1 MPER vaccine utility

Broadly neutralizing antibodies (bnAbs) against HIV-1 target conserved envelope (Env) epitopes to block viral replication. Here, using structural analyses, we provide evidence to explain why a vaccine targeting the membrane-proximal external region (MPER) of HIV-1 elicits antibodies with human bnAb-...

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Detalles Bibliográficos
Autores principales: Tan, Kemin, Chen, Junjian, Kaku, Yu, Wang, Yi, Donius, Luke, Khan, Rafiq Ahmad, Li, Xiaolong, Richter, Hannah, Seaman, Michael S., Walz, Thomas, Hwang, Wonmuk, Reinherz, Ellis L., Kim, Mikyung
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10632514/
https://www.ncbi.nlm.nih.gov/pubmed/37940661
http://dx.doi.org/10.1038/s41467-023-42097-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10632514/
https://www.ncbi.nlm.nih.gov/pubmed/37940661
http://dx.doi.org/10.1038/s41467-023-42097-6

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