Structural flexibility of apolipoprotein E-derived arginine-rich peptides improves their cell penetration capability

Amphipathic arginine-rich peptide, A2-17, exhibits moderate perturbation of lipid membranes and the highest cell penetration among its structural isomers. We investigated the direct cell-membrane penetration mechanism of the A2-17 peptide while focusing on structural flexibility. We designed conform...

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Detalles Bibliográficos
Autores principales: Takechi-Haraya, Yuki, Ohgita, Takashi, Usui, Akiko, Nishitsuji, Kazuchika, Uchimura, Kenji, Abe, Yasuhiro, Kawano, Ryuji, Konaklieva, Monika I., Reimund, Mart, Remaley, Alan T., Sato, Yoji, Izutsu, Ken-ichi, Saito, Hiroyuki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10632520/
https://www.ncbi.nlm.nih.gov/pubmed/37938626
http://dx.doi.org/10.1038/s41598-023-46754-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10632520/
https://www.ncbi.nlm.nih.gov/pubmed/37938626
http://dx.doi.org/10.1038/s41598-023-46754-0

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