Determining suitable surfactant concentration ranges to avoid protein unfolding in pharmaceutical formulations using UV analysis

Protein stability is fundamental to maintain pharmaceutical efficacy in the nascent field of biologics. One particular property that is essential for therapeutic effect is retention of the folded 3-dimensional conformation, i.e. once unfolding has occurred the biologic is often rendered inactive. In...

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Detalles Bibliográficos
Autores principales: Waters, Laura J., Whiteley, Joseph, Small, William, Mellor, Steve
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10632529/
https://www.ncbi.nlm.nih.gov/pubmed/37954313
http://dx.doi.org/10.1016/j.heliyon.2023.e21712

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10632529/
https://www.ncbi.nlm.nih.gov/pubmed/37954313
http://dx.doi.org/10.1016/j.heliyon.2023.e21712

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