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Determining suitable surfactant concentration ranges to avoid protein unfolding in pharmaceutical formulations using UV analysis
Protein stability is fundamental to maintain pharmaceutical efficacy in the nascent field of biologics. One particular property that is essential for therapeutic effect is retention of the folded 3-dimensional conformation, i.e. once unfolding has occurred the biologic is often rendered inactive. In...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Elsevier
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10632529/ https://www.ncbi.nlm.nih.gov/pubmed/37954313 http://dx.doi.org/10.1016/j.heliyon.2023.e21712 |