Activation of SIRT6 Deacetylation by DNA Strand Breaks

[Image: see text] SIRT6 is an emerging regulator of longevity. Overexpression of SIRT6 extends the lifespan of mice. Conversely, SIRT6 knockout mice demonstrate severe metabolic defects and a shortened lifespan. The discrepancy between SIRT6’s weak in vitro activity and robust in vivo activity has l...

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Detalles Bibliográficos
Autores principales: Kang, Wenjia, Hamza, Abu, Curry, Alyson M., Korade, Evan, Donu, Dickson, Cen, Yana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10633859/
https://www.ncbi.nlm.nih.gov/pubmed/37970049
http://dx.doi.org/10.1021/acsomega.3c04859

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10633859/
https://www.ncbi.nlm.nih.gov/pubmed/37970049
http://dx.doi.org/10.1021/acsomega.3c04859

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