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Activation of SIRT6 Deacetylation by DNA Strand Breaks
[Image: see text] SIRT6 is an emerging regulator of longevity. Overexpression of SIRT6 extends the lifespan of mice. Conversely, SIRT6 knockout mice demonstrate severe metabolic defects and a shortened lifespan. The discrepancy between SIRT6’s weak in vitro activity and robust in vivo activity has l...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Chemical Society
2023
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10633859/ https://www.ncbi.nlm.nih.gov/pubmed/37970049 http://dx.doi.org/10.1021/acsomega.3c04859 |