The burden of rare variants in DPYS gene is a novel predictor of the risk of developing severe fluoropyrimidine-related toxicity

BACKGROUND: Despite a growing number of publications highlighting the potential impact on the therapy outcome, rare genetic variants (minor allele frequency < 1%) in genes associated to drug adsorption, distribution, metabolism, and elimination are poorly studied. Previously, rare germline DPYD m...

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Detalles Bibliográficos
Autores principales: De Mattia, Elena, Polesel, Jerry, Silvestri, Marco, Roncato, Rossana, Scarabel, Lucia, Calza, Stefano, Spina, Michele, Puglisi, Fabio, Toffoli, Giuseppe, Cecchin, Erika
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10633914/
https://www.ncbi.nlm.nih.gov/pubmed/37946254
http://dx.doi.org/10.1186/s40246-023-00546-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10633914/
https://www.ncbi.nlm.nih.gov/pubmed/37946254
http://dx.doi.org/10.1186/s40246-023-00546-9

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