Polygenic risk for triglyceride levels in the presence of a high impact rare variant

BACKGROUND: Elevated triglyceride (TG) levels are a heritable and modifiable risk factor for cardiovascular disease and have well-established associations with common genetic variation captured in a polygenic risk score (PRS). In young adulthood, the 22q11.2 microdeletion conveys a 2-fold increased...

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Detalles Bibliográficos
Autores principales: Ying, Shengjie, Heung, Tracy, Thiruvahindrapuram, Bhooma, Engchuan, Worrawat, Yin, Yue, Blagojevic, Christina, Zhang, Zhaolei, Hegele, Robert A., Yuen, Ryan K. C., Bassett, Anne S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10634078/
https://www.ncbi.nlm.nih.gov/pubmed/37940981
http://dx.doi.org/10.1186/s12920-023-01717-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10634078/
https://www.ncbi.nlm.nih.gov/pubmed/37940981
http://dx.doi.org/10.1186/s12920-023-01717-2

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