Cargando…

Tacrolimus reverses pemphigus vulgaris serum-induced depletion of desmoglein in HaCaT cells via inhibition of heat shock protein 27 phosphorylation

BACKGROUND: Glucocorticoids are the first-line treatment for Pemphigus vulgaris (PV), but its serious side effects can be life-threatening for PV patients. Tacrolimus (FK506) has been reported to have an adjuvant treatment effect against PV. However, the mechanism underlying the inhibitory effect of...

Descripción completa

Detalles Bibliográficos
Autores principales:	Xie, Zhimin, Dai, Xiangnong, Li, Qingqing, Lin, Sifan, Ye, Xingdong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2023
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10634089/ https://www.ncbi.nlm.nih.gov/pubmed/37940861 http://dx.doi.org/10.1186/s12865-023-00582-z

Ejemplares similares

Non-Desmoglein Antibodies in Patients With Pemphigus Vulgaris
por: Amber, Kyle T., et al.
Publicado: (2018)

Autoantibodies other than Anti-desmogleins in Pemphigus Vulgaris Patients
por: Saleh, Marwah Adly, et al.
Publicado: (2017)

Identification of a Novel Non-desmoglein Autoantigen in Pemphigus Vulgaris
por: Di Lullo, Giulia, et al.
Publicado: (2019)

Proteomic definition of a desmoglein linear determinant common to Pemphigus vulgaris and Pemphigus foliaceous
por: Lucchese, Alberta, et al.
Publicado: (2006)

Long-lasting Localized Pemphigus Vulgaris without Detectable Serum Autoantibodies Against Desmoglein 3 and Desmoglein 1
por: Yoshifuku, Asuka, et al.
Publicado: (2016)

Do serum prolactin levels correlate with antibodies against desmoglein in pemphigus vulgaris?
por: Iraji, Fariba, et al.
Publicado: (2016)

Evaluation of desmoglein 1 and 3 autoantibodies in pemphigus vulgaris: correlation with disease severity
por: Delavarian, Zahra, et al.
Publicado: (2020)

Pemphigus vulgaris antigen, a desmoglein type of cadherin, is localized within keratinocyte desmosomes
Publicado: (1993)

An adult passive transfer mouse model to study desmoglein 3 signaling in pemphigus vulgaris
por: Schulze, Katja, et al.
Publicado: (2011)

Improving Treatment Outcome of Pemphigus Vulgaris on Vietnamese Patients by Using Desmoglein Elisa Test
por: Van, Anh Tran Thi, et al.
Publicado: (2019)

Desmogleins 1, 3, and E-cadherin immunohistochemical expression within mucocutaneous pemphigus vulgaris
por: Alshami, Muhanad Lebnan, et al.
Publicado: (2022)

Faster IgG4 Depletion Kinetics Observed for Anti-Desmoglein 3 Autoantibodies Following Rituximab Treatment in Patients with Pemphigus Vulgaris
por: BOCH, Katharina, et al.
Publicado: (2022)

Targeted Disruption of the Pemphigus Vulgaris Antigen (Desmoglein 3) Gene in Mice Causes Loss of Keratinocyte Cell Adhesion with a Phenotype Similar to Pemphigus Vulgaris
por: Koch, Peter J., et al.
Publicado: (1997)

Pathogenic activity of circulating anti-desmoglein-3 autoantibodies isolated from pemphigus vulgaris patients
por: Narbutt, Joanna, et al.
Publicado: (2012)

HLA class II antigens in Croatian patients with pemphigus vulgaris and their correlation with anti-desmoglein antibodies
por: Lakoš Jukić, Ines, et al.
Publicado: (2023)

High Levels of Anti-Heat Shock Protein 27 Antibody in Pemphigus Vulgaris
por: Yazdanpanah, Mohammad Javad, et al.
Publicado: (2013)

Selective Elevation of Antibodies to Desmoglein 1 during the Transition from Mucocutaneous to Cutaneous Type Pemphigus Vulgaris
por: Matsuda-Hirose, Haruna, et al.
Publicado: (2013)

Keratin Retraction and Desmoglein3 Internalization Independently Contribute to Autoantibody-Induced Cell Dissociation in Pemphigus Vulgaris
por: Schlögl, Elisabeth, et al.
Publicado: (2018)

A New Solid-Phase Immunosorbent for Selective Binding of Desmoglein 3 Autoantibodies in Patients with Pemphigus Vulgaris
por: Abramova, T. V., et al.
Publicado: (2020)

Plakophilins, desmogleins, and pemphigus: the tail wagging the dog
por: Ellebrecht, Christoph T., et al.
Publicado: (2014)

Autoantibodies against desmoglein 2 are not pathogenic in pemphigus()
por: Miguel, Marcela Calixto Brandão, et al.
Publicado: (2022)

Desmoglein compensation hypothesis fidelity assessment in Pemphigus
por: Sielski, Lauren, et al.
Publicado: (2022)

A Novel In Vivo Active Pemphigus Model Targeting Desmoglein1 and Desmoglein3: A Tool Representing All Pemphigus Variants
por: Lotti, Roberta, et al.
Publicado: (2023)

Thalidomide Alleviates Apoptosis, Oxidative Damage and Inflammation Induced by Pemphigus Vulgaris IgG in HaCat Cells and Neonatal Mice Through MyD88
por: Luan, Chunyan, et al.
Publicado: (2023)

Salivary Desmoglein Enzyme-Linked Immunosorbent Assay for Diagnosis of Pemphigus Vulgaris: A Noninvasive Alternative Test to Serum Assessment
por: Mortazavi, Hossein, et al.
Publicado: (2015)

Loss of flotillin expression results in weakened desmosomal adhesion and Pemphigus vulgaris-like localisation of desmoglein-3 in human keratinocytes
por: Völlner, Frauke, et al.
Publicado: (2016)

Anti-Thyroid Peroxidase Reactivity Is Heightened in Pemphigus Vulgaris and Is Driven by Human Leukocyte Antigen Status and the Absence of Desmoglein Reactivity
por: Seiffert-Sinha, Kristina, et al.
Publicado: (2018)

Generation of an anti-desmoglein 3 antibody without pathogenic activity of pemphigus vulgaris for therapeutic application to squamous cell carcinoma
por: Funahashi, Shin-Ichi, et al.
Publicado: (2018)

Acantholysis may precede elevation of circulating anti‐desmoglein 3 antibody levels in pemphigus vulgaris presenting with desquamative gingivitis
por: Endo, Hiroyasu, et al.
Publicado: (2019)

Autoantibodies against Desmoglein 1 and 3 in South Tunisian pemphigus
por: Jerbi, Ameni, et al.
Publicado: (2021)

FcRn Antagonism Leads to a Decrease of Desmoglein-Specific B Cells: Secondary Analysis of a Phase 2 Study of Efgartigimod in Pemphigus Vulgaris and Pemphigus Foliaceus
por: Maho-Vaillant, Maud, et al.
Publicado: (2022)

TRB3 is elevated in psoriasis vulgaris lesions and mediates HaCaT cells proliferation in vitro
por: Yu, Xiao-Jing, et al.
Publicado: (2017)

Immunoadsorption of Desmoglein-3-Specific IgG Abolishes the Blister-Inducing Capacity of Pemphigus Vulgaris IgG in Neonatal Mice
por: Hofrichter, Maxi, et al.
Publicado: (2018)

Sustained CD19(+)CD27(+) Memory B Cell Depletion after Rituximab Treatment in Patients with Pemphigus Vulgaris
por: BOCH, Katharina, et al.
Publicado: (2022)

Pemphigus vulgaris
por: Tamgadge, Sandhya, et al.
Publicado: (2011)

Pemphigus vulgaris
por: Porro, Adriana Maria, et al.
Publicado: (2019)

Prediction of desmoglein-3 peptides reveals multiple shared T-cell epitopes in HLA DR4- and DR6- associated Pemphigus vulgaris
por: Tong, Joo Chuan, et al.
Publicado: (2006)

Intracellular domain of desmoglein 3 (pemphigus vulgaris antigen) confers adhesive function on the extracellular domain of E-cadherin without binding catenins
Publicado: (1995)

Evolving Mechanisms in the Pathophysiology of Pemphigus Vulgaris: A Review Emphasizing the Role of Desmoglein 3 in Regulating p53 and the Yes-Associated Protein
por: Rehman, Ambreen, et al.
Publicado: (2021)

T cell autoimmunity and immune regulation to desmoglein 3, a pemphigus autoantigen
por: Takahashi, Hayato, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_srncu95pah7ju6cj6ua7oi33a8