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Phase Separation and Fibrillization of Human Annexin A7 Are Mediated by Its Proline-Rich Domain

[Image: see text] Human annexin A7, a calcium- and phospholipid-binding protein, governs calcium homeostasis, plasma membrane repair, apoptosis, and tumor progression. A7 contains an N-terminal proline-rich domain (PRD; 180 residues, ∼24% prolines) that determines its functional specificity. Using m...

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Detalles Bibliográficos
Autores principales: Yu, Chenrong, Nelson, Spencer L., Meisl, Georg, Ghirlando, Rodolfo, Deshmukh, Lalit
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10634317/
https://www.ncbi.nlm.nih.gov/pubmed/37788367
http://dx.doi.org/10.1021/acs.biochem.3c00349