Enitociclib, a Selective CDK9 Inhibitor, Induces Complete Regression of MYC+ Lymphoma by Downregulation of RNA Polymerase II Mediated Transcription

Double-hit diffuse large B-cell lymphoma (DH-DLBCL) is an aggressive, and often refractory, type of B-cell non–Hodgkin lymphoma (NHL) characterized by rearrangements in MYC and BCL2. Cyclin-dependent kinase 9 (CDK9) regulates transcriptional elongation and activation of transcription factors, includ...

Descripción completa

Detalles Bibliográficos
Autores principales: Frigault, Melanie M., Mithal, Arushi, Wong, Harvey, Stelte-Ludwig, Beatrix, Mandava, Vinay, Huang, Xin, Birkett, Joseph, Johnson, Amy J., Izumi, Raquel, Hamdy, Ahmed
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for Cancer Research 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10634346/
https://www.ncbi.nlm.nih.gov/pubmed/37882668
http://dx.doi.org/10.1158/2767-9764.CRC-23-0219

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10634346/
https://www.ncbi.nlm.nih.gov/pubmed/37882668
http://dx.doi.org/10.1158/2767-9764.CRC-23-0219

Ejemplares similares