Cargando…

Enitociclib, a Selective CDK9 Inhibitor, Induces Complete Regression of MYC+ Lymphoma by Downregulation of RNA Polymerase II Mediated Transcription

Double-hit diffuse large B-cell lymphoma (DH-DLBCL) is an aggressive, and often refractory, type of B-cell non–Hodgkin lymphoma (NHL) characterized by rearrangements in MYC and BCL2. Cyclin-dependent kinase 9 (CDK9) regulates transcriptional elongation and activation of transcription factors, includ...

Descripción completa

Detalles Bibliográficos
Autores principales:	Frigault, Melanie M., Mithal, Arushi, Wong, Harvey, Stelte-Ludwig, Beatrix, Mandava, Vinay, Huang, Xin, Birkett, Joseph, Johnson, Amy J., Izumi, Raquel, Hamdy, Ahmed
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Association for Cancer Research 2023
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10634346/ https://www.ncbi.nlm.nih.gov/pubmed/37882668 http://dx.doi.org/10.1158/2767-9764.CRC-23-0219

Ejemplares similares

Discovery of VIP236, an αvβ3-Targeted Small-Molecule–Drug Conjugate with Neutrophil Elastase-Mediated Activation of 7-Ethyl Camptothecin Payload for Treatment of Solid Tumors
por: Lerchen, Hans-Georg, et al.
Publicado: (2023)

P1269: VIP152 IS A NOVEL CDK9 INHIBITOR WITH IMPROVED SELECTIVITY, TARGET MODULATION, AND CARDIAC SAFETY IN PATIENTS WITH LYMPHOMA
por: Frigault, M., et al.
Publicado: (2022)

A Small Molecule–Drug Conjugate (SMDC) Consisting of a Modified Camptothecin Payload Linked to an α(V)ß(3) Binder for the Treatment of Multiple Cancer Types
por: Lerchen, Hans-Georg, et al.
Publicado: (2022)

MEDB-81. Combined inhibition of CDK11 and EZH2 results in regression of MYC-amplified medulloblastoma
por: Wang, Dong, et al.
Publicado: (2022)

Targeting MYC dependency in ovarian cancer through inhibition of CDK7 and CDK12/13
por: Zeng, Mei, et al.
Publicado: (2018)

CDK13 cooperates with CDK12 to control global RNA polymerase II processivity
por: Fan, Zheng, et al.
Publicado: (2020)

Cdk2: a key regulator of the senescence control function of Myc
por: Hydbring, Per, et al.
Publicado: (2010)

Combined BET bromodomain and CDK2 inhibition in MYC-driven medulloblastoma
por: Bolin, Sara, et al.
Publicado: (2018)

MEDB-80. CDK8 promotes stemness of MYC-driven medulloblastoma
por: Wang, Dong, et al.
Publicado: (2022)

MYC is downregulated by a mitochondrial checkpoint mechanism
por: Zhang, Xiaonan, et al.
Publicado: (2017)

CDK9 keeps RNA polymerase II on track
por: Egloff, Sylvain
Publicado: (2021)

Targeting cyclin-dependent kinase 1 (CDK1) but not CDK4/6 or CDK2 is selectively lethal to MYC-dependent human breast cancer cells
por: Kang, Jian, et al.
Publicado: (2014)

CDK9-mediated transcription elongation is required for MYC addiction in hepatocellular carcinoma
por: Huang, Chun-Hao, et al.
Publicado: (2014)

MYC Modulation around the CDK2/p27/SKP2 Axis
por: Hydbring, Per, et al.
Publicado: (2017)

Combining PARP and CDK4/6 inhibitors in MYC driven ovarian cancer
por: Konecny, Gottfried E.
Publicado: (2019)

MYC up-regulation confers vulnerability to dual inhibition of CDK12 and CDK13 in high-risk Group 3 medulloblastoma
por: Pitolli, Consuelo, et al.
Publicado: (2023)

VIP152 is a selective CDK9 inhibitor with pre-clinical in vitro and in vivo efficacy in chronic lymphocytic leukemia
por: Sher, Steven, et al.
Publicado: (2022)

MYC pathway activation in triple-negative breast cancer is synthetic lethal with CDK inhibition
por: Horiuchi, Dai, et al.
Publicado: (2012)

Targeted Downregulation of MYC through G-quadruplex Stabilization by DNAi
por: Psaras, Alexandra Maria, et al.
Publicado: (2021)

A Selective Small‐Molecule c‐Myc Degrader Potently Regresses Lethal c‐Myc Overexpressing Tumors
por: Xu, Ying, et al.
Publicado: (2022)

Binding to DNA of the RNA-polymerase II C-terminal domain allows discrimination between Cdk7 and Cdk9 phosphorylation
por: Lolli, Graziano
Publicado: (2009)

De novo MYC addiction as an adaptive response of cancer cells to CDK4/6 inhibition
por: Tarrado‐Castellarnau, Míriam, et al.
Publicado: (2017)

Myc stimulates cell cycle progression through the activation of Cdk1 and phosphorylation of p27
por: García-Gutiérrez, Lucía, et al.
Publicado: (2019)

PTPN18 promotes colorectal cancer progression by regulating the c-MYC-CDK4 axis
por: Li, Chao, et al.
Publicado: (2020)

MEDB-28. CDK9 is a druggable mediator sustaining Myc-driven circuitry in medulloblastoma
por: Madhavan, Krishna, et al.
Publicado: (2022)

MYC-mediated resistance to trametinib and HCQ in PDAC is overcome by CDK4/6 and lysosomal inhibition
por: Silvis, Mark R., et al.
Publicado: (2023)

Anetumab ravtansine inhibits tumor growth and shows additive effect in combination with targeted agents and chemotherapy in mesothelin-expressing human ovarian cancer models
por: Quanz, Maria, et al.
Publicado: (2018)

CDK9-dependent RNA polymerase II pausing controls transcription initiation
por: Gressel, Saskia, et al.
Publicado: (2017)

Brief inactivation of c-Myc is not sufficient for sustained regression of c-Myc-induced tumours of pancreatic islets and skin epidermis
por: Pelengaris, Stella, et al.
Publicado: (2004)

The Flavonoid Apigenin Downregulates CDK1 by Directly Targeting Ribosomal Protein S9
por: Iizumi, Yosuke, et al.
Publicado: (2013)

CDK5RAP3 Participates in Autophagy Regulation and Is Downregulated in Renal Cancer
por: Li, Jun, et al.
Publicado: (2019)

JWA suppresses proliferation in trastuzumab-resistant breast cancer by downregulating CDK12
por: Liang, Yan, et al.
Publicado: (2021)

Myc targeted CDK18 promotes ATR and homologous recombination to mediate PARP inhibitor resistance in glioblastoma
por: Ning, Jian-Fang, et al.
Publicado: (2019)

CDK7 controls E2F- and MYC-driven proliferative and metabolic vulnerabilities in multiple myeloma
por: Yao, Yao, et al.
Publicado: (2023)

MDB-37. CDK9 IS A DRUGGABLE MEDIATOR SUSTAINING MYC-DRIVEN TRANSCRIPTIONAL CIRCUITRY IN MEDULLOBLASTOMA
por: Krishna, Madhavan, et al.
Publicado: (2023)

c-myc regulates the sensitivity of breast cancer cells to palbociclib via c-myc/miR-29b-3p/CDK6 axis
por: Ji, Wenfei, et al.
Publicado: (2020)

Integrative analysis of RNA polymerase II and transcriptional dynamics upon MYC activation
por: de Pretis, Stefano, et al.
Publicado: (2017)

SIRT7-dependent deacetylation of CDK9 activates RNA polymerase II transcription
por: Blank, Maximilian F., et al.
Publicado: (2017)

The Cdk8 kinase module regulates interaction of the mediator complex with RNA polymerase II
por: Osman, Sara, et al.
Publicado: (2021)

Sulforaphane-cysteine downregulates CDK4 /CDK6 and inhibits tubulin polymerization contributing to cell cycle arrest and apoptosis in human glioblastoma cells
por: Li, Juntao, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_u31p2v2tnq5e2k8qoc5fk6op6u