Dissecting signaling regulators driving AXL-mediated bypass resistance and associated phenotypes by phosphosite perturbations

Receptor tyrosine kinase (RTK)-targeted therapies are often effective but invariably limited by drug resistance. A major mechanism of acquired resistance involves “bypass” switching to alternative pathways driven by non-targeted RTKs that restore proliferation. One such RTK is AXL whose overexpressi...

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Detalles Bibliográficos
Autores principales: Creixell, Marc, Taylor, Scott D., Gerritsen, Jacqueline, Bae, Song Yi, Jiang, Mingxuan, Augustin, Teresa, Loui, Michelle, Boixo, Carmen, Creixell, Pau, White, Forest M, Meyer, Aaron S
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10634689/
https://www.ncbi.nlm.nih.gov/pubmed/37961516
http://dx.doi.org/10.1101/2023.10.20.563266

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10634689/
https://www.ncbi.nlm.nih.gov/pubmed/37961516
http://dx.doi.org/10.1101/2023.10.20.563266

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