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Mammalian circadian clock proteins form dynamic interacting microbodies distinct from phase separation

Liquid-liquid phase separation (LLPS) underlies diverse biological processes. Because most LLPS studies were performed in vitro or in cells that overexpress protein, the physiological relevance of LLPS is unclear. PERIOD proteins are central mammalian circadian clock components and interact with oth...

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Detalles Bibliográficos
Autores principales: Xie, Pancheng, Xie, Xiaowen, Ye, Congrong, Dean, Kevin M., Laothamatas, Isara, Taufique, S K Tahajjul, Takahashi, Joseph, Yamazaki, Shin, Xu, Ying, Liu, Yi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10634710/
https://www.ncbi.nlm.nih.gov/pubmed/37961341
http://dx.doi.org/10.1101/2023.10.19.563153