Disparate pathways for extrachromosomal DNA biogenesis and genomic DNA repair

Oncogene amplification on extrachromosomal DNA (ecDNA) is a pervasive driver event in cancer, yet our understanding of how ecDNA forms is limited. Here, we couple a CRISPR-based method for induction of ecDNA with extensive characterization of newly formed ecDNA to examine ecDNA biogenesis. We find t...

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Detalles Bibliográficos
Autores principales: Rose, John C., Wong, Ivy Tsz-Lo, Daniel, Bence, Jones, Matthew G., Yost, Kathryn E., Hung, King L., Curtis, Ellis J., Mischel, Paul S., Chang, Howard Y.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10634728/
https://www.ncbi.nlm.nih.gov/pubmed/37961138
http://dx.doi.org/10.1101/2023.10.22.563489

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10634728/
https://www.ncbi.nlm.nih.gov/pubmed/37961138
http://dx.doi.org/10.1101/2023.10.22.563489

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